NDLI: Association analyses of osteoprotegerin gene polymorphisms with bone mineral density in Chinese postmenopausal women.

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Association analyses of osteoprotegerin gene polymorphisms with bone mineral density in Chinese postmenopausal women.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Feng He, Chunlei Chen, Gang Li, Fangcai Gao, Hui
Description	Author Affiliation: Zhang F ( Orthopedics Department, The Second Affiliated Hospital Zhejiang University College of Medicine, No. 88 Jiefang Road, Hangzhou 310009, People's Republic of China.)
Abstract	Osteoprotegerin gene (OPG) is an important candidate gene of osteoporosis. The objective of this study was to evaluate the association between OPG gene polymorphisms and bone mineral density (BMD). A total of 336 Chinese postmenopausal women were included in this study. OPG gene polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), created restriction site-PCR (CRS-PCR) and DNA sequencing methods. BMD was evaluated at the lumbar spine (L(2-4)), total hip and femoral neck. Two single-nucleotide polymorphisms (SNPs) (g.21775C>T and g.23367T>C) were identified and the association analysis showed significant difference of spine BMD among different g.23367T>C genotype, subjects with the genotype TT was significantly higher than those of genotype TC and CC. Such a significant difference was not observed at the neck hip BMD and total hip BMD. The g.21775C>T polymorphism was not significantly associated with spine BMD, total hip BMD and neck hip BMD in the studied subjects. These findings suggested that OPG gene polymorphisms were associated with BMD in Chinese postmenopausal women. Results from this study will be helpful in further studies to determine the role of OPG gene in osteoporosis.
File Format	HTM / HTML
ISSN	13570560
Issue Number	1
Volume Number	30
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2013-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Bone Density Gene Frequency Humans Middle Aged Genotype Genetic Predisposition To Disease Absorptiometry, Photon Journal Article Osteoprotegerin Asian Continental Ancestry Group Osteoporosis, Postmenopausal Polymorphism, Restriction Fragment Length Polymerase Chain Reaction Postmenopause Genetics Female Polymorphism, Single Nucleotide Aged Discipline Oncology
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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