NDLI: Pharmacokinetics of amantadine in cats.

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Pharmacokinetics of amantadine in cats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Siao, K. T. Pypendop, B. H. Stanley, S. D. Ilkiw, J. E.
Description	Country affiliation: United States Author Affiliation: Siao KT ( Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, USA.)
Abstract	This study reports the pharmacokinetics of amantadine in cats, after both i.v. and oral administration. Six healthy adult domestic shorthair female cats were used. Amantadine HCl (5 mg/kg, equivalent to 4 mg/kg amantadine base) was administered either intravenously or orally in a crossover randomized design. Blood samples were collected immediately prior to amantadine administration, and at various times up to 1440 min following intravenous, or up to 2880 min following oral administration. Plasma amantadine concentrations were determined by liquid chromatography-mass spectrometry, and plasma amantadine concentration-time data were fitted to compartmental models. A two-compartment model with elimination from the central compartment best described the disposition of amantadine administered intravenously in cats, and a one-compartment model best described the disposition of oral amantadine in cats. After i.v. administration, the apparent volume of distribution of the central compartment and apparent volume of distribution at steady-state [mean ± SEM (range)], and the clearance and terminal half-life [harmonic mean ± jackknife pseudo-SD (range)] were 1.5 ± 0.3 (0.7-2.5) L/kg, 4.3 ± 0.2 (3.7-5.0) L/kg, 8.2 ± 2.1 (5.9-11.4) mL·min/kg, and 348 ± 49 (307-465) min, respectively. Systemic availability [mean ± SEM (range)] and terminal half-life after oral administration [harmonic mean ± jackknife pseudo-SD (range)] were 130 ± 11 (86-160)% and 324 ± 41 (277-381) min, respectively.
File Format	HTM / HTML
ISSN	01407783
Issue Number	6
Volume Number	34
e-ISSN	13652885
Journal	Journal of Veterinary Pharmacology and Therapeutics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-12-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Therapeutics Discipline Veterinary Medicine Discipline Pharmacology Amantadine Pharmacokinetics Antiviral Agents Cats Blood Administration, Oral Administration & Dosage Animals Chromatography, Liquid Veterinary Cross-over Studies Female Half-life Infusions, Intravenous Least-squares Analysis Metabolic Clearance Rate Tandem Mass Spectrometry Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Veterinary Pharmacology

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