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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gaunt, P. S. Langston, C. Wrzesinski, C. Gao, D. Adams, P. Crouch, L. Sweeney, D. Endris, R. |
| Description | Country affiliation: United States Author Affiliation: Gaunt PS ( Mississippi State University, College of Veterinary Medicine, Stoneville, MS, USA. gaunt@cvm.msstate.edu) |
| Abstract | Plasma distribution and elimination of florfenicol in channel catfish were investigated after a single dose (10 mg/kg) of intravenous (i.v.) or oral administration in freshwater at a mean water temperature of 25.4 °C. Florfenicol concentrations in plasma were analyzed by means of liquid chromatography with MS/MS detection. After i.v. florfenicol injection, the terminal half-life (t(1/2)), volume of distribution at steady state (V(ss)), and central volume of distribution (V(c)) were 8.25 h, 0.9 and 0.381 L/kg, respectively. After oral administration of florfenicol, the terminal t(1/2), C(max), T(max), and oral bioavailability (F) were 9.11 h, 7.6 µg/mL, 9.2 h, and 1.09, respectively. There was a lag absorption time of 1.67 h in oral dosing. Results from these studies support that 10 mg florfenicol/kg body weight in channel catfish is an efficacious dosage following oral administration. |
| File Format | HTM / HTML |
| ISSN | 01407783 |
| Issue Number | 5 |
| Volume Number | 35 |
| e-ISSN | 13652885 |
| Journal | Journal of Veterinary Pharmacology and Therapeutics |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2012-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Therapeutics Discipline Veterinary Medicine Discipline Pharmacology Anti-bacterial Agents Pharmacokinetics Ictaluridae Blood Thiamphenicol Analogs & Derivatives Administration, Oral Animals Administration & Dosage Area Under Curve Biological Availability Chromatography, Liquid Half-life Injections, Intravenous Tandem Mass Spectrometry Clinical Trial Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Veterinary Pharmacology |
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