NDLI: Pharmacokinetics of pioglitazone after multiple oral dose administration in horses.

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Pharmacokinetics of pioglitazone after multiple oral dose administration in horses.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wearn, J. M. G. Crisman, M. V. Davis, J. L. Geor, R. J. Hodgson, D. R. Suagee, J. K. Ashraf-Khorassani, M. McCutcheon, L. J.
Description	Country affiliation: United States Author Affiliation: Wearn JM ( Department of Large Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.)
Abstract	Pioglitazone is a thiazolidinedione class of antidiabetic agent with proven efficacy in increasing insulin sensitivity in humans with noninsulin-dependent diabetes mellitus, a syndrome of insulin resistance sharing similarities with equine metabolic syndrome. The purpose of this study was to determine the pharmacokinetics of pioglitazone in adult horses following multiple oral dose administration. Pioglitazone hydrochloride (1 mg/kg) was administered orally for 11 doses at 24-h intervals, and plasma samples were collected. Initially, a pilot study was performed using one horse; and thereafter the drug was administered to six horses. Samples were analyzed by liquid chromatography with tandem mass spectrometry, and pharmacokinetic parameters were calculated using noncompartmental modeling. The maximum plasma concentration was 509.1 ± 413.5 ng/mL achieved at 1.88 ± 1.39 h following oral administration of the first dose, and 448.1 ± 303.5 ng/mL achieved at 2.83 ± 1.81 h (mean ± SD) following the eleventh dose. Apparent elimination half-life was 9.94 ± 4.57 and 9.63 ± 5.33 h after the first and eleventh dose, respectively. This study showed that in healthy horses, pioglitazone administered at a daily oral dose of 1 mg/kg results in plasma concentrations and total drug exposure approximating, but slightly below, those considered therapeutic in humans.
File Format	HTM / HTML
ISSN	01407783
Issue Number	3
Volume Number	34
e-ISSN	13652885
Journal	Journal of Veterinary Pharmacology and Therapeutics
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-06-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Therapeutics Discipline Veterinary Medicine Discipline Pharmacology Horses Metabolism Hypoglycemic Agents Pharmacokinetics Thiazolidinediones Administration, Oral Animals Chromatography, High Pressure Liquid Veterinary Drug Administration Schedule Female Half-life Administration & Dosage Tablets Tandem Mass Spectrometry Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Veterinary Pharmacology

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