NDLI: Lipid-based vectors for siRNA delivery.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Shubiao Zhi, Defu Huang, Leaf
Description	Country affiliation: United States Author Affiliation: Zhang S ( Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.)
Abstract	siRNA therapeutics has developed rapidly and already there are clinical trials ongoing or planned; however, the delivery of siRNA into cells, tissues or organs remains to be a major obstacle. Lipid-based vectors hold the most promising position among non-viral vectors, as they have a similar structure to cell or organelle membranes. But when used in the form of liposomes, these vectors have shown some problems. Therefore, either the nature of lipids themselves or forms used should be improved. As a novel class of lipid like materials, lipidoids have the advantages of easy synthesis and the ability for delivering siRNA to obtain excellent silencing activity. However, the toxicities of lipidoids have not been thoroughly studied. pH responsive lipids have also gained great attention recently, though some of the amine-based lipids are not novel in terms of chemical structures. More complex self-assembly structures, such as LPD (LPH) and LCP, may provide a good solution to siRNA delivery. They have demonstrated controlled particle morphology and size and siRNA delivery activity for both in vitro and in vivo.
File Format	HTM / HTML
ISSN	1061186X
e-ISSN	10292330
DOI	10.3109/1061186X.2012.719232
Journal	Journal of Drug Targeting
Issue Number	9
Volume Number	20
Language	English
Publisher	Taylor & Francis
Publisher Date	2012-11-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Pharmacology Lipids Chemistry Rna Interference Rna, Small Interfering Administration & Dosage Animals Gene Silencing Genetic Therapy Hydrogen-ion Concentration Adverse Effects Particle Size Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science

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