NDLI: High-density lipoproteins for the systemic delivery of short interfering RNA.

Please wait, while we are loading the content...

High-density lipoproteins for the systemic delivery of short interfering RNA.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	McMahon, Kaylin Marie Thaxton, Colby Shad
Description	Author Affiliation: McMahon KM ( Northwestern University, Feinberg School of Medicine, Department of Urology , 303 E. Chicago Avenue, Tarry 16-703, Chicago, IL 60611 , USA +1 312 503 9354 )
Abstract	INTRODUCTION: RNA interference (RNAi) is a powerful mechanism for gene silencing with the potential to greatly impact the development of new therapies for many human diseases. Short interfering RNAs (siRNAs) may be the ideal molecules for therapeutic RNAi. However, therapeutic siRNAs face significant challenges that must be overcome prior to widespread clinical use. Many efforts have been made to overcome the hurdles associated with systemic administration of siRNA; however, current approaches are still limited. As such, there is an urgent need to develop new strategies for siRNA delivery that have the potential to impact a broad spectrum of systemic diseases. AREAS COVERED: This review focuses on the promise of siRNA therapies and highlights current siRNA delivery methods. With an eye toward new strategies, this review first introduces high-density lipoprotein (HDL) and describes its natural biological functions, and then transitions into how HDLs may provide significant opportunities as next-generation siRNA delivery vehicles. Importantly, this review describes how synthetic HDLs leverage the natural ability of HDL to stabilize and deliver siRNAs. EXPERT OPINION: HDLs are natural nanoparticles that are critical to understanding the systemic delivery of therapeutic nucleic acids, like siRNA. Methods to synthesize biomimetic HDLs are being explored, and data demonstrate that this type of delivery vehicle may be highly beneficial for targeted and efficacious systemic delivery of siRNAs.
File Format	HTM / HTML
ISSN	17425247
e-ISSN	17447593
DOI	10.1517/17425247.2014.866089
Journal	Expert Opinion on Drug Delivery
Issue Number	2
Volume Number	11
Language	English
Publisher	Taylor & Francis
Publisher Date	2014-02-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Analytical Chemistry Discipline Pharmacology Lipoproteins, Hdl Administration & Dosage Rna, Small Interfering Animals Gene Silencing Chemistry Nanoparticles Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Lipid-based vectors for siRNA delivery.

Progress and perspective of inorganic nanoparticle-based siRNA delivery systems.

Multifunctional gold nanorods for siRNA gene silencing and photothermal therapy.

Efficient cytosolic delivery of siRNA using HDL-mimicking nanoparticles.

Recent advances of siRNA delivery by nanoparticles.

Mesoporous silica nanoparticles facilitate delivery of siRNA to shutdown signaling pathways in mammalian cells.

Hybrid Lipid-Polymer Nanoparticles for Sustained siRNA Delivery and Gene Silencing

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates.

Efficient and gentle siRNA delivery by magnetofection.

High-density lipoproteins for the systemic delivery of short interfering RNA.

Similar Documents

Lipid-based vectors for siRNA delivery.

Progress and perspective of inorganic nanoparticle-based siRNA delivery systems.

Multifunctional gold nanorods for siRNA gene silencing and photothermal therapy.

Efficient cytosolic delivery of siRNA using HDL-mimicking nanoparticles.

Recent advances of siRNA delivery by nanoparticles.

Mesoporous silica nanoparticles facilitate delivery of siRNA to shutdown signaling pathways in mammalian cells.

Hybrid Lipid-Polymer Nanoparticles for Sustained siRNA Delivery and Gene Silencing

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates.

Efficient and gentle siRNA delivery by magnetofection.

High-density lipoproteins for the systemic delivery of short interfering RNA.