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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tertti, Kristiina Eskola, Eeva Rönnemaa, Tapani Haataja, Leena |
| Description | Country affiliation: Finland Author Affiliation: Tertti K ( Departments of *Obstetrics and Gynecology, Pediatric Neurology, Medicine, University of Turku and Turku University Hospital, Turku, Finland.) |
| Abstract | OBJECTIVE: To compare cognitive, language, and motor skills and results of neurological examination in 2-year-old children born to mothers with gestational diabetes mellitus treated with metformin with those treated with insulin. METHOD: The children of mothers with gestational diabetes mellitus randomized to metformin (n = 75) or insulin (n = 71) treatment during pregnancy were examined by standardized developmental and neurological measures; the Bayley Scales of Infant and Toddler Development (Bayley-III) and the Hammersmith Infant Neurological Examination. RESULTS: There were no significant differences between the metformin and insulin groups in the Bayley Scales of Infant and Toddler Development (Bayley-III) test of cognitive scale (p = .12), receptive communication (p = .14) or expressive communication (p = .75), fine motor scale (p = .10) or gross motor scale (p = .13), or the global scores of Hammersmith Infant Neurological Examination (p = .14). None of the children had a clinically significant developmental problem. However, compared with age-adjusted norms, a trend for weaker language performance was observed in both study groups. CONCLUSION: No differences in neurodevelopmental outcome were seen in 2-year-old children born to mothers with gestational diabetes mellitus (GDM) treated with insulin or metformin during pregnancy. The results suggest that children born to mothers with GDM and exposed to metformin in utero do not systematically need extensive formal neurodevelopmental assessment in early childhood. |
| File Format | HTM / HTML |
| ISSN | 0196206X |
| Issue Number | 9 |
| Volume Number | 36 |
| e-ISSN | 15367312 |
| Journal | Journal of Developmental & Behavioral Pediatrics |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2015-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Pediatrics Child Development Drug Effects Diabetes, Gestational Drug Therapy Insulin Adverse Effects Metformin Prenatal Exposure Delayed Effects Chemically Induced Adult Child, Preschool Female Humans Therapeutic Use Male Neuropsychological Tests Pregnancy Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Developmental and Educational Psychology Pediatrics, Perinatology and Child Health Psychiatry and Mental Health |
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