Loading...
Please wait, while we are loading the content...
Similar Documents
The First 1000 Days: Impact of Prenatal Tobacco Smoke Exposure on Hospitalization Due to Preschool Wheezing
| Content Provider | MDPI |
|---|---|
| Author | Collet, Cyrielle Fayon, Michael Francis, Florence Galode, François Bui, Stephanie Debelleix, Stephane |
| Copyright Year | 2021 |
| Description | Preschool wheezing and related hospitalization rates are increasing. Prenatal tobacco smoke exposure (PTSE) increases the risk of wheezing, yet >20% of French women smoke during pregnancy. In this observational retrospective monocentric study, we assessed the link between PTSE and hospital admissions. We included infants <2 years of age admitted for acute wheezing. A phone interview with mothers was completed by electronic records. The primary endpoint was the ratio of cumulative duration of the hospitalization stays (days)/age (months). 129 children were included (36.4% exposed to PTSE vs. 63.6% unexposed). There was a significant difference in the duration of hospitalization/age: 0.9 days/month (exposed) vs. 0.58 days/month (unexposed) (p = 0.008). Smoking one cigarette/day during pregnancy was associated with an increase in hospitalization duration of 0.055 days/month (r = 0.238, p = 0.006). In the multi-variable analysis, this positive association persisted (β = 0.04, p = 0.04; standardized β = 0.27, p = 0.03). There was a trend towards a dose-effect relationship between PTSE and other important parameters associated with hospital admissions. We have demonstrated a dose-effect relationship, without a threshold effect, between PTSE and duration of hospitalization for wheezing in non-premature infants during the first 2 years of life. Prevention campaigns for future mothers should be enforced. |
| Starting Page | 1089 |
| e-ISSN | 22279032 |
| DOI | 10.3390/healthcare9081089 |
| Journal | Healthcare |
| Issue Number | 8 |
| Volume Number | 9 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-08-23 |
| Access Restriction | Open |
| Subject Keyword | Healthcare Pediatrics and Child Health Asthma Child Preschool Prenatal Exposure Delayed Effects Pregnancy Smoking Adverse Effect |
| Content Type | Text |
| Resource Type | Article |
