NDLI: Transcripts of PTTG and growth factors bFGF and IGF-1 are correlated in pituitary adenomas.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chamaon, K. Kanakis, D. Mawrin, C. Dietzmann, K. Kirches, E.
Description	Country affiliation: Germany Author Affiliation: Chamaon K ( Department of Neuropathology, Otto-von-Guericke University of Magdeburg, Magdeburg, Germany.)
Abstract	The reasons for the increase of pituitary tumor-transforming gene (PTTG) transcripts in about 90% of pituitary adenomas are still not fully understood, although upregulation by basic fibroblast growth factor (bFGF) has been discussed as a potential cause. A possible influence of the Insulin like Growth Factor 1 (IGF-1) might be of interest, since this protein is also synthesized in most pituitary adenomas. Moreover, the principal regulation of the PTTG gene by IGF-1 and Insulin has been demonstrated in astrocytoma and breast cancer cells. We analyzed a large group (103 patients) of unselected clinical pituitary adenoma samples. From total RNA of frozen tumor samples (all subtypes) cDNA ( COMPLEMENTARY DNA) was synthesized and transcripts of PTTG, bFGF, IGF-1 were measured by Real-Time-PCR. Not only mRNA ( MESSENGER RNA) levels of bFGF, but also of IGF-1, correlated strongly with PTTG transcripts. This result was obtained, when all pituitary adenoma samples were included in the statistical calculations, irrespective of their subclassification. Our study suggests a connection between PTTG and IGF-1 in pituitary adenomas.
File Format	HTM / HTML
ISSN	09477349
Issue Number	2
Volume Number	118
e-ISSN	14393646
Journal	Experimental and Clinical Endocrinology & Diabetes
Language	English
Publisher	Thieme
Publisher Date	2010-02-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Endocrinology Adenoma Genetics Fibroblast Growth Factor 2 Insulin-like Growth Factor I Neoplasm Proteins Pituitary Gland Metabolism Pituitary Neoplasms Gene Expression Regulation, Neoplastic Humans Rna, Messenger Reverse Transcriptase Polymerase Chain Reaction Securin Journal Article
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

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