NDLI: Oral phosphate supplementation corrects hypophosphatemia and normalizes plasma FGF23 and 25-hydroxyvitamin D3 levels in women with chronic metabolic acidosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Domrongkitchaiporn, S. Disthabanchong, S. Cheawchanthanakij, R. Niticharoenpong, K. Stitchantrakul, W. Charoenphandhu, N. Krishnamra, N.
Description	Country affiliation: Thailand Author Affiliation: Domrongkitchaiporn S ( Consortium for Calcium and Bone Research, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.)
Abstract	BACKGROUND: Chronic metabolic acidosis (CMA) is known to induce renal phosphate wasting and hypophosphatemia by enhancing bone resorption and inhibiting renal phosphate reabsorption. However, nothing is known regarding changes in the plasma levels of phosphate-regulating hormones during CMA, especially in humans with normal kidney function. METHODS: Fifteen healthy Thai female volunteers were given NH (4)Cl orally for 7 days to induce CMA with or without oral phosphate supplementation. Blood and 24-h urine specimens were collected prior to and after CMA induction. Plasma concentrations and fractional excretion of calcium and inorganic phosphate as well as plasma levels of fibroblast growth factor (FGF) 23, 25(OH)D (3), 1,25(OH) (2)D (3) and intact parathyroid hormone (iPTH) were determined. RESULTS: CMA led to hypophosphatemia and hypocalcemia with increases in the fractional excretion of calcium and phosphate. Plasma concentrations of FGF23, 25(OH)D (3) and iPTH were decreased, whereas that of 1,25(OH) (2)D (3) was increased. After oral phosphate supplementation, CMA-induced changes in the concentrations of the studied ions, FGF23 and 25(OH)D (3), but not those of 1,25(OH) (2)D (3) and iPTH, were diminished. CONCLUSIONS: The CMA-induced hypophosphatemia was likely to initiate a negative feedback response, thereby leading to reduction in the plasma levels of hyperphosphaturic hormones, FGF23 and PTH. An increase in the plasma 1,25(OH) (2)D (3) level, despite diminishing 25(OH)D (3) storage pool, may help enhance the intestinal phosphate absorption. Oral phosphate supplementation abolished the effects of CMA on FGF23 and 25(OH)D (3) levels, suggesting that the plasma phosphate concentration is the primary regulator of the plasma levels of these hormones during CMA.
File Format	HTM / HTML
ISSN	09477349
Issue Number	2
Volume Number	118
e-ISSN	14393646
Journal	Experimental and Clinical Endocrinology & Diabetes
Language	English
Publisher	Thieme
Publisher Date	2010-02-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Endocrinology Acidosis Chemically Induced Drug Therapy Calcifediol Blood Fibroblast Growth Factors Hypophosphatemia Phosphates Therapeutic Use Complications Administration, Oral Adult Ammonium Chloride Chronic Disease Female Humans Etiology Middle Aged Statistics, Nonparametric Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology

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