NDLI: Involvement of the antioxidant system in differential sensitivity of Carcinus maenas to fenitrothion exposure.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rodrigues, A. P. Gravato, C. Guimarães, L.
Spatial Coverage	Portugal
Description	Country affiliation: Portugal Author Affiliation: Rodrigues AP ( Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal. arodrigues@ciimar.up.pt.)
Abstract	Carcinus maenas is an invertebrate with worldwide distribution and high ability to adapt to different environments, which is frequently used in environmental monitoring. Despite this, it is not clear how historical exposure to moderate contamination may influence sensitivity to further chemical stress in this important decapod species. This study investigated differential responses to organophosphate fenitrothion of C. maenas from a moderately contaminated estuary and a low impacted one, using in vitro and in vivo biomarker assays. To clarify potential differences in sensitivity, a biochemical characterisation of muscle cholinesterases was first performed. The results indicated acetylcholinesterase (AChE) as the main form present in C. maenas muscle. Exposure assays revealed that crabs from the moderately contaminated site were less sensitive to fenitrothion showing lower AChE inhibition than those from the low impacted site. Other biomarker changes detected in these animals were: increased anaerobic metabolism (muscle lactate dehydrogenase), enhanced phase II biotransformation (glutathione S-transferases in the digestive gland) and antioxidant defences (i.e., activities of glutathione reductase, glutathione peroxidase and catalase, and levels of total glutathiones in the digestive gland). Altogether, the results pointed out a role for the glutathione redox system towards tolerance to fenitrothion exposure.
File Format	HTM / HTML
ISSN	20507887
Issue Number	10
Volume Number	15
e-ISSN	20507895
Journal	Environmental Science: Processes & Impacts
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2013-10-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Environmental Health Antioxidants Metabolism Brachyura Drug Effects Environmental Monitoring Methods Fenitrothion Toxicity Water Pollutants, Chemical Acetylcholinesterase Animals Biological Markers Enzymology Growth & Development Analysis Lipid Peroxidation Muscles Oxidation-reduction Portugal Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Public Health, Environmental and Occupational Health Management, Monitoring, Policy and Law

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