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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Goodchild, Christopher G. Frederich, Markus Zeeman, Stephan I. |
| Description | Author Affiliation: Goodchild CG ( Department of Marine Sciences, University of New England, 11 Hills Beach Rd., Biddeford, ME 04005, USA); Frederich M ( Department of Marine Sciences, University of New England, 11 Hills Beach Rd., Biddeford, ME 04005, USA. Electronic address: mfrederich@une.edu.); Zeeman SI ( Department of Marine Sciences, University of New England, 11 Hills Beach Rd., Biddeford, ME 04005, USA. Electronic address: szeeman@une.edu.) |
| Abstract | Environmental stress may alter the bioenergetic balance of organisms by resulting in greater energy investment into detoxification processes, which diverts energy from other biological functions. Here, we examine responses to triclosan (TCS) exposure in a freshwater mussel across multiple biological levels: behavioral (e.g., burrowing and movement activity), organismal (e.g., metabolic rate and heart rate), and subcellular (e.g., gene expression and protein abundance/activity). At the subcellular level, we employed both energetic (i.e., AMP-activated protein kinase (AMPK)) and traditional (i.e., heat shock protein (HSP70), superoxide dismutase (SOD), glutathione-S-transferase (GST)) biomarkers. We found a significant reduction in burrowing and movement behaviors, a 1.8-fold increase in total-AMPK protein abundance, and a 2.8-fold increase in AMPK activity after 21d. GST activity increased after 4d, but not after 21d. Our findings suggest that TCS exposure results in an energetic tradeoff between detoxification at the cellular level and whole-animal activity. |
| File Format | HTM / HTML |
| ISSN | 15320456 |
| Volume Number | 179 |
| Journal | Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Discipline Pharmacology Cell Membrane Drug Effects Energy Metabolism Fresh Water Motor Activity Triclosan Toxicity Amp-activated Protein Kinases Metabolism Animals Bivalvia Dose-response Relationship, Drug Physiology Journal Article Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s. |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Physiology Health, Toxicology and Mutagenesis Medicine Aquatic Science Biochemistry Toxicology Animal Science and Zoology |
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