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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Abreu, Murilo S. Giacomini, Ana Cristina V. Gusso, Darlan Rosa, João G. S. Koakoski, Gessi Kalichak, Fabiana Idalêncio, Renan Oliveira, Thiago A. Barcellos, Heloísa H. A. Bonan, Carla D. Barcellos, Leonardo J. G. |
| Description | Country affiliation: Brazil Author Affiliation: Abreu MS ( Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.); Giacomini AC ( Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil); Gusso D ( Universidade de Passo Fundo (UPF), BR 285, Bairro São José, Passo Fundo, RS, 99052-900, Brazil.); Rosa JG ( Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.); Koakoski G ( Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.); Kalichak F ( Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.); Idalêncio R ( Universidade de Passo Fundo (UPF), BR 285, Bairro São José, Passo Fundo, RS, 99052-900, Brazil); Oliveira TA ( Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.); Barcellos HH ( Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil); Bonan CD ( Laboratório de Neuroquímica e Psicofarmacologia, Programa de Pós-Graduação em Biologia Celular e Molecular, Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Av. Ipiranga, 6681, Porto Alegre, RS, Brazil.); Barcellos LJ ( Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil) |
| Abstract | Psychotropic medications are widely used, and their prescription has increased worldwide, consequently increasing their presence in aquatic environments. Therefore, aquatic organisms can be exposed to psychotropic drugs that may be potentially dangerous, raising the question of whether these drugs are attractive or aversive to fish. To answer this question, adult zebrafish were tested in a chamber that allows the fish to escape or seek a lane of contaminated water. These attraction and aversion paradigms were evaluated by exposing the zebrafish to the presence of acute contamination with these compounds. The zebrafish were attracted by certain concentrations of diazepam, fluoxetine, risperidone and buspirone, which were most likely detected by olfaction, because this behavior was absent in anosmic fish. These findings suggest that despite their deleterious effects, certain psychoactive drugs attract fish. |
| File Format | HTM / HTML |
| ISSN | 15320456 |
| Volume Number | 179 |
| Journal | Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology Discipline Pharmacology Avoidance Learning Drug Effects Psychotropic Drugs Toxicity Water Pollutants, Chemical Animals Physiology Dose-response Relationship, Drug Female Male Motor Activity Zebrafish Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Physiology Health, Toxicology and Mutagenesis Medicine Aquatic Science Biochemistry Toxicology Animal Science and Zoology |
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