NDLI: Developmental lead exposure causes startle response deficits in zebrafish.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Rice, Clinton Ghorai, Jugal K. Zalewski, Kathryn Weber, Daniel N.
Description	Country affiliation: United States Author Affiliation: Rice C ( Department of Biology, American University, Washington, DC 20016, USA.)
Abstract	Lead (Pb(2+)) exposure continues to be an important concern for fish populations. Research is required to assess the long-term behavioral effects of low-level concentrations of Pb(2+) and the physiological mechanisms that control those behaviors. Newly fertilized zebrafish embryos (<2h post fertilization; hpf) were exposed to one of three concentrations of lead (as PbCl(2)): 0, 10, or 30 nM until 24 hpf. (1) Response to a mechanosensory stimulus: Individual larvae (168 hpf) were tested for response to a directional, mechanical stimulus. The tap frequency was adjusted to either 1 or 4 taps/s. Startle response was recorded at 1000 fps. Larvae responded in a concentration-dependent pattern for latency to reaction, maximum turn velocity, time to reach V(max) and escape time. With increasing exposure concentrations, a larger number of larvae failed to respond to even the initial tap and, for those that did respond, ceased responding earlier than control larvae. These differences were more pronounced at a frequency of 4 taps/s. (2) Response to a visual stimulus: Fish, exposed as embryos (2-24 hpf) to Pb(2+) (0-10 µM) were tested as adults under low light conditions (≈ 60 µW/m(2)) for visual responses to a rotating black bar. Visual responses were significantly degraded at Pb(2+) concentrations of 30 nM. These data suggest that zebrafish are viable models for short- and long-term sensorimotor deficits induced by acute, low-level developmental Pb(2+) exposures.
File Format	HTM / HTML
ISSN	0166445X
e-ISSN	18791514
DOI	10.1016/j.aquatox.2011.08.014
Journal	Aquatic Toxicology
Issue Number	3-4
Volume Number	105
Language	English
Publisher	Elsevier
Publisher Date	2011-10-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Toxicology Escape Reaction Drug Effects Toxicity Reflex, Startle Water Pollutants, Chemical Zebrafish Physiology Animals Dose-response Relationship, Drug Embryo, Nonmammalian Larva Pharmacokinetics Time Factors Toxicity Tests, Acute Embryology Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Aquatic Science

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