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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Whitt, Michael A. Cox, Michelle E. Kansal, Rita Cox, John V. |
| Description | Country affiliation: United States Author Affiliation: Whitt MA ( Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.) |
| Abstract | To investigate the role of cytoplasmic sequences in directing transmembrane protein trafficking through the Golgi, we analyzed the sorting of VSV tsO45 G fusions with either the native G cytoplasmic domain (G) or an alternative cytoplasmic tail derived from the chicken AE1-4 anion exchanger (G(AE) ). At restrictive temperature G(AE) and G accumulated in the ER, and upon shifting the cells to permissive temperature both proteins folded and underwent transport through the Golgi. However, G(AE) and G did not form hetero-oligomers upon the shift to permissive temperature and they progressed through the Golgi with distinct kinetics. In addition, the transport of G through the proximal Golgi was Arf1 and COPI-dependent, while G(AE) progression through the proximal Golgi was Arf1 and COPI-independent. Although Arf1 did not regulate the sorting of G(AE) in the cis-Golgi, Arf1 did regulate the exit of G(AE) from the TGN. The trafficking of G(AE) through the Golgi was similar to that of the native AE1-4 anion exchanger, in that the progression of both proteins through the proximal Golgi was Arf1-independent, while both required Arf1 to exit the TGN. We propose that the differential recognition of cytosolic signals in membrane-spanning proteins by the Arf1-dependent sorting machinery may influence the rate at which cargo progresses through the Golgi. |
| File Format | HTM / HTML |
| ISSN | 13989219 |
| Issue Number | 3 |
| Volume Number | 16 |
| e-ISSN | 16000854 |
| Journal | Traffic |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2015-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Physiology Adp-ribosylation Factor 1 Metabolism Golgi Apparatus Protein Transport Physiology Signal Transduction Animals Anion Exchange Protein 1, Erythrocyte Cos Cells Cell Line Cercopithecus Aethiops Chickens Coat Protein Complex I Cytoplasm Cytosol Dogs Endoplasmic Reticulum Kinetics Madin Darby Canine Kidney Cells Membrane Proteins Protein Structure, Tertiary Journal Article Research Support, N.i.h., Extramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Genetics Structural Biology Molecular Biology Biochemistry |
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