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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kokotos, Alexandros C. Cousin, Michael A. |
| Description | Country affiliation: United kingdom Author Affiliation: Kokotos AC ( Centre for Integrative Physiology, George Square, University of Edinburgh, Edinburgh, EH8 9XD, UK.) |
| Abstract | Central nerve terminals contain a small number of synaptic vesicles (SVs) that must sustain the fidelity of neurotransmission across a wide range of stimulation intensities. For this to be achieved, nerve terminals integrate a number of complementary endocytosis modes whose activation spans the breadth of these neuronal stimulation patterns. Two such modes are ultrafast endocytosis and activity-dependent bulk endocytosis, which are triggered by stimuli at either end of the physiological range. Both endocytosis modes generate endosomes directly from the nerve terminal plasma membrane, before the subsequent production of SVs from these structures. This review will discuss the current knowledge relating to the molecular mechanisms involved in the generation of SVs from nerve terminal endosomes, how this relates to other mechanisms of SV production and the functional role of such SVs. |
| File Format | HTM / HTML |
| ISSN | 13989219 |
| Issue Number | 3 |
| Volume Number | 16 |
| e-ISSN | 16000854 |
| Journal | Traffic |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2015-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Physiology Central Nervous System Physiology Endosomes Nerve Endings Synaptic Vesicles Animals Cell Membrane Endocytosis Journal Article Research Support, Non-u.s. Gov't Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Genetics Structural Biology Molecular Biology Biochemistry |
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