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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zefirov, A. L. Zakharov, A. V. Mukhametzyanov, R. D. Petrov, A. M. Sitdikova, G. F. |
| Description | Country affiliation: RUSSIA Author Affiliation: Zefirov AL ( Kazan State Medical University, 49 Butlerov Street, 420012, Kazan, Russia. zefirova1@rambler.ru) |
| Abstract | Experiments on the mouse diaphragm muscle using intracellular microelectrode recordings and fluorescence microscopy were performed to study the dynamics of transmitter secretion and synaptic vesicle recycling processes (the exocytosis-endocytosis cycle) in motor nerve endings (NE) during prolonged rhythmic stimulation (20 impulses/sec). During stimulation, there were triphasic changes in the amplitude of endplate potentials (EPP): an initial rapid reduction, followed by prolonged (1-2 min) stabilization of amplitude, i.e., a plateau, and then a further slow decrease. Restoration of EPP amplitude after stimulation for 3 min occurred over a period of several seconds. Loading of synaptic vesicles with the fluorescent endocytic stain FM1-43 showed that rhythmic stimulation led to a gradual (over 5-6 min) decrease in NE fluorescence, demonstrating exocytosis of synaptic vesicles. Quantum analysis of the electrophysiological data and comparison of these data with results from fluorescence studies suggested that mouse NE have a high rate of endocytosis and reutilization of synaptic vesicles (the mean recycling time was about 50 sec), which may support the maintenance of reliable synaptic transmission during prolonged high-frequency activity. The sizes of the release-ready and recycling pools of synaptic vesicles were determined quantitatively. It is suggested that vesicle recycling in mouse NE occurs via a short, rapid pathway with incorporation into the recycling pool. Vesicles of the reserve pool are not used for transmitter secretion in the stimulation conditions used here. |
| File Format | HTM / HTML |
| ISSN | 00970549 |
| Issue Number | 3 |
| Volume Number | 39 |
| e-ISSN | 1573899X |
| Journal | Neuroscience and Behavioral Physiology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2009-03-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Behavioral Sciences Discipline Neurology Diaphragm Injuries Physiology Presynaptic Terminals Synaptic Vesicles Animals Electric Stimulation Endocytosis In Vitro Techniques Mice Microelectrodes Microscopy, Fluorescence Synaptic Transmission Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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