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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lin, Tser-Sheng Wu, Chin-Ching Wu, Jyun-De Wei, Chun-Han |
| Description | Country affiliation: Taiwan Author Affiliation: Lin TS ( Department of Safety, Health, and Environmental Engineering, National United University, Miaoli, Taiwan. tslin@nuu.edu.tw) |
| Abstract | A total of 130 male glass workers, including 33 administrative workers, 18 batch house workers, 42 craftsmen, and 37 melting process workers, were recruited to investigate the potential DNA damage resulting from toxic element exposure. The occupational exposure to trace elements, including arsenic (As), cadmium (Cd), manganese (Mn), nickel (Ni), lead (Pb), and selenium (Se), was estimated by their urinary levels as internal doses. In addition, all participants filled a self-filled questionnaire indicating their individual information. The average levels of urinary As, Cd, Mn, Ni, Pb, Se, and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were 282.3 ± 464.6, 3.07 ± 5.39, 3.81 ± 11.43, 81.48 ± 138.9, 18.23 ± 49.61, 165.2 ± 224.9, and 17.21 ± 26.34 µg/g creatinine, respectively. The urinary levels of 8-OHdG and toxic elements were strongly associated with the work nature of the worker, with an exception of Mn and Pb. In contrast, the levels of toxic element were not influenced by age, smoking behavior, and alcohol consumption. The urinary 8-OHdG was found significantly higher in higher internal exposure groups of As, Cd, Ni, and Se. However, the stepwise multiple regression models showed that urinary 8-OHdG was only associated with urinary As and heat stress but inversely with age. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 6 |
| Volume Number | 28 |
| e-ISSN | 14770393 |
| Journal | Toxicology and Industrial Health |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2012-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology Arsenic Poisoning Urine Arsenic Dna Damage Deoxyguanosine Analogs & Derivatives Occupational Diseases Occupational Exposure Adverse Effects Adult Analysis Of Variance Etiology Biological Markers Creatinine Glass Hot Temperature Humans Industry Male Metals, Heavy Toxicity Middle Aged Noise Analysis Regression Analysis Questionnaires Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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