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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | El-Shinnawy, Nashwa A. |
| Description | Country affiliation: Egypt Author Affiliation: El-Shinnawy NA ( Department of Zoology, Women College for Arts, Science and Education, Ain Shams University, Cairo, Egypt elshinnawy_nashwa@hotmail.com.) |
| Abstract | The present study investigated the impact of two doses, 500 mg/kg and 1000 mg/kg, of di(2-ethylhexyl) phthalate (DEHP) and studied the possible therapeutic dose of celery oil seed extract for 6 weeks on some atheroscelerogenic, obesogenic, antioxidant and liver functions in rats. Both doses of DEHP caused over-expression of peroxisome proliferator-activated receptor alpha (PPAR ) messenger RNA with significant increase in liver weights, relative liver weights, serum cholesterol (Chol), triglycerides, low-density lipoprotein Chol, liver total lipids, along with an increase in the activities of serum aspartate aminotransferase, alanine aminotransferase, serum endothelin 1 and liver tissue thiobarbituric acid reactive substances (TBARS). Additionally, DEHP administration to rats resulted in significant decrease in final body weights, serum total protein, albumin, liver total protein and serum total nitric oxide. Our study confirmed the role of oral combination of Apium graveolens (celery) oil seed extract at small cumulative doses (50 µl/kg for 6 weeks) with DEHP in ameliorating the toxicological effects of DEHP, which was revealed in reducing the expression of PPAR , lipid profile, with restoring liver functions, vascular oxidative stress and inhibition of TBARS activity. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 4 |
| Volume Number | 31 |
| e-ISSN | 14770393 |
| Journal | Toxicology and Industrial Health |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2015-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology Apium Graveolens Chemistry Phthalic Acids Toxicity Plant Oils Pharmacology Plasticizers Protective Agents Animals Body Weight Drug Effects Drug Interactions Lipids Blood Liver Male Organ Size Ppar Alpha Genetics Metabolism Polymerase Chain Reaction Rats Seeds Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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