NDLI: Measured density and calculated baricity of custom-compounded drugs for chronic intrathecal infusion.

Please wait, while we are loading the content...

Year: 2017 Volume: 42

Year: 2016 Volume: 41

Year: 2015 Volume: 40

Year: 2014 Volume: 39

Year: 2013 Volume: 38

Year: 2012 Volume: 37

Year: 2011 Volume: 36

Year: 2011 Volume: 36 Issue: 6

Year: 2011 Volume: 36 Issue: 5

Year: 2011 Volume: 36 Issue: 4

Year: 2011 Volume: 36 Issue: 3

Year: 2011 Volume: 36 Issue: 2

Year: 2011 Volume: 36 Issue: 1

Ultrasound-guided peripheral nerve block in a patient with neurofibromatosis.

Accurate placement of ultrasound-guided lateral popliteal-sciatic perineural catheters.

Injection of injectates is more than just for 'opening the perineural space'.

Continuous femoral nerve block under ultrasound guidance: perineural opening before catheter placement is perhaps no longer necessary.

Ultrasound refraction artifact is unlikely a response to duplication of brachial plexus.

Practical considerations in preparing the pig carcass spine phantom.

Investigation of puncture angles needs clinically defined insertion points.

Specialist's knowledge of local anesthetic systemic toxicity.

Neurologic deficit in conjunction with intraneural injection: more questions than answers.

An unsubstantiated condemnation of intraneural injection.

Intraneural injections.

Recognizing dangerous intraneural injection: is it the musician or the instrument?

Practice advisories by the American Society of Regional Anesthesia and Pain Medicine: grading the evidence and making the grade.

From preemptive to preventive analgesia: time to reconsider the role of perioperative peripheral nerve blocks?

Measured density and calculated baricity of custom-compounded drugs for chronic intrathecal infusion.

Testing haptic sensations for spinal anesthesia.

Computed tomography celiac trunk topography relating to celiac plexus block.

A randomized comparison of infraclavicular and supraclavicular continuous peripheral nerve blocks for postoperative analgesia.

Effect of continuous posttraumatic intrathecal nocistatin on the development of mechanical allodynia.

Use of low-dose steroids in decreasing cytokine release during bilateral total knee replacement.

Lidocaine pretreatment with tourniquet versus lidocaine-propofol admixture for attenuating propofol injection pain: a randomized controlled trial.

Postvoid residuals remain unchanged in patients with postoperative thoracic epidural analgesia after thoracotomy.

Spinal anesthesia for orthopedic surgery: a detailed video assessment of quality.

Mechanical hypersensitivity, sympathetic sprouting, and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain.

Use of a spinal cord stimulator for treatment of Martorell hypertensive ulcer.

Evidence basis for regional anesthesia in multidisciplinary fast-track surgical care pathways.

Year: 2010 Volume: 35

Year: 2009 Volume: 34

Year: 2008 Volume: 33

Year: 2007 Volume: 32

Year: 2005 Volume: 30

Measured density and calculated baricity of custom-compounded drugs for chronic intrathecal infusion.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hejtmanek, Michael R. Harvey, Tracy D. Bernards, Christopher M.
Description	Country affiliation: United States Author Affiliation: Hejtmanek MR ( Department of Anesthesiology, Virginia Mason Medical Center, University of Washington, 1100 Ninth Avenue, Seattle, WA 98101, USA.)
Abstract	BACKGROUND AND OBJECTIVES: To minimize the frequency that intrathecal pumps require refilling, drugs are custom compounded at very high concentrations. Unfortunately, the baricity of these custom solutions is unknown, which is problematic, given baricity's importance in determining the spread of intrathecally administered drugs. Consequently, we measured the density and calculated the baricity of clinically relevant concentrations of multiple drugs used for intrathecal infusion. METHODS: Morphine, clonidine, bupivacaine, and baclofen were weighed to within 0.0001 g and diluted in volumetric flasks to produce solutions of known concentrations (morphine 1, 10, 25, and 50 mg/mL; clonidine 0.05, 0.5, 1, and 3 mg/mL; bupivacaine 2.5, 5, 10, and 20 mg/mL; baclofen 1, 1.5, 2, and 4 mg/mL). The densities of the solutions were measured at 37°C using the mechanical oscillation method. A 'best-fit' curve was calculated for plots of concentration versus density for each drug. RESULTS: All prepared solutions of clonidine and baclofen were hypobaric. Higher concentrations of morphine and bupivacaine were hyperbaric, whereas lower concentrations were hypobaric. The relationship between concentration and density is linear for morphine (r > 0.99) and bupivacaine (r > 0.99) and logarithmic for baclofen (r = 0.96) and clonidine (r = 0.98). CONCLUSIONS: This is the first study to examine the relationship between concentration and density for custom drug concentrations commonly used in implanted intrathecal pumps. We calculated an equation that defines the relationship between concentration and density for each drug. Using these equations, clinicians can calculate the density of any solution made from the drugs studied here.
File Format	HTM / HTML
ISSN	10987339
Issue Number	1
Volume Number	36
e-ISSN	15328651
Journal	Regional Anesthesia and Pain Medicine
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2011-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Neurology Discipline Anesthesiology Baclofen Chemistry Bupivacaine Clonidine Morphine Administration & Dosage Chemistry, Pharmaceutical Drug Administration Schedule Drug Compounding Infusion Pumps, Implantable Infusions, Parenteral Linear Models Models, Chemical Oscillometry Pharmaceutical Solutions Time Factors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in