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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kopper, László |
| Description | Country affiliation: Hungary Author Affiliation: Kopper L ( Ist Department of Pathology and Experimental Cancer Research, Semmelweis University, Ulloi út 26, 1085, Budapest, Hungary. kopper@korb1.sote.hu) |
| Abstract | Lapatinib is an oral dual tyrosine kinase inhibitor targeting EGFR1 and EGFR2 (HER2). Phase I trials have shown that lapatinib is well tolerated, with mild diarrhea and skin rush as common adverse effects, and low cardiotoxicity. Phase II and III trials provided evidences on clinical effectiveness in advanced or metastatic breast cancer and potential against brain metastases. Lapatinib is active in combination with trastuzumab and in trastuzumab-resistant patients, moreover it has synergistic action with capecitabine. Several clinical trials are in progress to explore the effectiveness of lapatinib in other combinations and against several tumor types. |
| File Format | HTM / HTML |
| ISSN | 12194956 |
| Issue Number | 1 |
| Volume Number | 14 |
| e-ISSN | 15322807 |
| Journal | Pathology & Oncology Research |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2008-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Oncology Breast Neoplasms Drug Therapy Quinazolines Therapeutic Use Antibodies, Monoclonal Antibodies, Monoclonal, Humanized Antineoplastic Agents Antineoplastic Combined Chemotherapy Protocols Metabolism Clinical Trials As Topic Drug Resistance, Neoplasm Female Humans Neoplasms Administration & Dosage Adverse Effects Pharmacokinetics Receptor, Epidermal Growth Factor Antagonists & Inhibitors Receptor, Erbb-2 Trastuzumab Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pathology and Forensic Medicine Oncology |
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