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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Herszényi, László Sipos, Ferenc Galamb, Orsolya Solymosi, Norbert Hritz, István Miheller, Pál Berczi, Lajos Molnár, Béla Tulassay, Zsolt |
| Description | Country affiliation: Hungary Author Affiliation: Herszényi L ( 2nd Department of Medicine, Semmelweis University, 1088 Szentkirályi str. 46, Budapest, Hungary. hersz@bel2.sote.hu) |
| Abstract | It has been proposed that matrix metalloproteinases (MMPs) play a role in tumor invasion. We determined protein expression of matrix metalloproteinase-9 (MMP-9) in colorectal cancer (CRC), corresponding normal mucosa and colorectal adenomas. For confirmation of immunohistochemical results MMP-9 TaqMan RT-PCR analysis was performed. Expression of MMP-9 was determined on paraffin embedded biopsy sections by immunohistochemistry in 31 CRC patients (from cancer tissue and corresponding normal mucosa) and in 30 patients with adenoma (nine adenomas with high grade of dysplasia). MMP-9 immunostaining was determined semi-quantitatively. For Taqman RT-PCR analyses normal mucosa (n = 5), adenoma without (n = 6) and with high grade dysplasia (n = 7) and CRC (n = 10) were investigated. Statistical analysis with ANOVA, LSD test and correlation analysis were performed. P value of <0.05 was considered significant. The MMP-9 expression in CRC was significantly higher compared to adenomas or the normal mucosa (P = 0.001). Significantly higher expression of MMP-9 has been observed in adenomas with high grade dysplasia compared to other adenomas or normal colon (P < 0.001). Diffuse strong MMP-9 expression was present in tumor as well as in stromal cells. In adenoma samples, dysplastic epithelial cells showed moderate intensive cytoplasmic MMP-9 expression, with a clear-cut differentiation between dysplastic and non-dysplastic areas. Staining intensity correlated with the grade of CRC. We demonstrate a significantly higher expression of MMP-9 in adenoma with high grade dysplasia-CRC sequence as compared to normal tissue. The over-expression of MMP-9 strongly suggests its association with colorectal carcinogenesis. |
| File Format | HTM / HTML |
| ISSN | 12194956 |
| Issue Number | 1 |
| Volume Number | 14 |
| e-ISSN | 15322807 |
| Journal | Pathology & Oncology Research |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2008-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Oncology Adenocarcinoma Metabolism Adenoma Colon Colorectal Neoplasms Intestinal Mucosa Matrix Metalloproteinase 9 Pathology Aged Analysis Of Variance Female Humans Immunohistochemistry Methods Male Genetics Middle Aged Reverse Transcriptase Polymerase Chain Reaction Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pathology and Forensic Medicine Oncology |
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