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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Horvath, Ildiko Fanny Szanto, Antonia Csiki, Zoltan Szodoray, Peter Zeher, Margit |
| Abstract | Rheumatoid nodules are well established manifestations of rheumatoid arthritis but in the lungs they are very rare according to the literature. In our study we present the case of a 34-year-old woman with rheumatoid arthritis and secondary Sjögren's syndrome who developed multiplex rheumatoid nodules in the lungs 3 years after initiating leflunomide therapy. During leflunomide therapy we did not detect inflammation in the joints. Surprisingly, in November 2005 she started to cough, had low grade fever and low back pain. On the chest X-ray there were multiplex necrobiotic nodules in the lungs. All bacteriological, viral and fungal investigations including tuberculosis, serological tests and cytology were negative. The X-ray, video-associated thoracoscopy and repeated biopsy of the lung followed by histology of the samples proved intrapulmonary rheumatoid nodules, caused by leflunomide. |
| File Format | HTM / HTML |
| ISSN | 12194956 |
| Issue Number | 1 |
| Volume Number | 14 |
| e-ISSN | 15322807 |
| Journal | Pathology & Oncology Research |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2008-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Oncology Arthritis, Rheumatoid Drug Therapy Isoxazoles Therapeutic Use Multiple Pulmonary Nodules Pathology Rheumatoid Nodule Adult Diagnosis Chronic Disease Female Humans Lung Diseases Complications Sjogren's Syndrome Thoracoscopy Case Reports Letter |
| Content Type | Text |
| Resource Type | Case study Article |
| Subject | Cancer Research Pathology and Forensic Medicine Oncology |
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