NDLI: Squamotransitional cell carcinoma of the vagina: diagnosis and clinical management: a literature review starting from a rare case report.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Patrelli, Tito Silvio Silini, Enrico Maria Berretta, Roberto Thai, Elena Gizzo, Salvatore Bacchi Modena, Alberto Nardelli, Giovanni Battista
Description	Country affiliation: Italy Author Affiliation: Patrelli TS ( Ob/Gyn Clinic, University of Parma, Parma, Italy. titosilvio.patrelli@gmail.com)
Abstract	Primary squamotransitional cell carcinoma (STCC) is rare squamous cell tumor variant resembling transitional cell carcinoma (TCC) of the urinary tract. STCC occurs rarely in the vagina and its clinical and pathological correlates are poorly known. We report a unique case of a 66-year-old Italian woman with STCC of the vagina. A biopsy of the tumor was performed. The tumor qualified as a STCC. Following biopsy, the patient underwent radical hysterectomy (Piver's III-type) with bilateral salpingo-oophorectomy, upper colpectomy, appendicectomy, peritoneal cytology, and lymphadenectomy. The patient is now healthy without evidence of recurrence at 30 months after surgery. Pathologically, cytoarchitectural characteristics distinguish this histotype (STCC) from conventional squamous cell carcinoma of the genital tract. The cytokeratin staining pattern (CK7 positive and CK20 negative), the p63 expression and the positivity for p16ink4a and high-risk HPV are the main elements of differential diagnosis. We suggest that STCC of the vagina should be treated by radical surgery, possibly followed by adjuvant therapy based on staging results and should receive a long-term follow-up.
File Format	HTM / HTML
ISSN	12194956
Issue Number	1
Journal	Pathology & Oncology Research
Volume Number	17
e-ISSN	15322807
Language	English
Publisher	Springer
Publisher Date	2011-03-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Carcinoma, Squamous Cell Pathology Surgery Vaginal Neoplasms Aged Female Humans Case Reports Journal Article Review
Content Type	Text
Resource Type	Case study Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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