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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Valcz, Gábor Krenács, Tibor Sipos, Ferenc Leiszter, Katalin Tóth, Kinga Balogh, Zsófia Csizmadia, Annamária Muzes, Györgyi Molnár, Béla Tulassay, Zsolt |
| Description | Country affiliation: Hungary Author Affiliation: Valcz G ( 2nd Department of Internal Medicine, Cell Analysis Laboratory, Semmelweis University, Szentkiralyi Street 46, 1088 Budapest, Hungary. valczg@yahoo.com) |
| Abstract | Bone marrow derived mesenchymal stem cells (BM-MSCs) take part in the colonic mucosal regeneration. They are multipotent cells, which can be identified with both negative (i.e. CD13, CD 14, CD45, c-Kit, major histocompatibility complex /MHC class I and II) and positive (i.e. CD54 (ICAM1), CD133, CD146 (MCAM), CD166, Flk-1, Sca-1, Thy-1, stage-specific antigen I /SSEA-I and Musashi-1, HLA class I) markers. These cells can repopulate the gastrointestinal mucosa as they may differentiate into stromal- (i.e. myofi-broblast) or epithelial-like (Paneth-, epithel-, goblet or enteroendocrin) cells without proliferation. During the mesenchymal to epithelial transition (MET) stem cells enter the epithelial layer and take up epithelial cell-like properties. Rarely BM-MSCs may retain their stem cell characteristics and are capable of producing progeny. The isolated lymphoid aggregates may serve as a platform from where BM-MSCs migrate to the nearby crypts as mediated by several chemoattractant proteins, which are expressed in injured tissue. The number of BM-MSCs is influenced by the degree of inflammation. In this review we summarize the current information about the role of BM-MSCs in the repair progress of injured colonic epithelium and their potential clinical applications. |
| File Format | HTM / HTML |
| ISSN | 12194956 |
| Issue Number | 1 |
| Volume Number | 17 |
| e-ISSN | 15322807 |
| Journal | Pathology & Oncology Research |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2011-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Oncology Bone Marrow Cells Cytology Colon Physiology Intestinal Mucosa Mesenchymal Stromal Cells Multipotent Stem Cells Animals Humans Regeneration Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pathology and Forensic Medicine Oncology |
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