NDLI: Loss of MTSS1 expression is an independent prognostic factor for Hilar cholangiocarcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Fei Liu, Yulong Zhang, Hao
Description	Country affiliation: China Author Affiliation: Wang F ( Department of Surgery, Eastern Hepatobiliary Hospital, Shanghai, China.)
Abstract	Metastasis suppressor 1 (MTSS1) is a novel metastasis suppressor gene in a variety of cancers. This study aimed to detect MTSS1 expression in normal and cancerous tissue specimens from Chinese patients with hilarcholangiocarcinoma to determine the association with clinicopathological parameters and survival. Tissue microarrays containing normal and tumor specimens were constructed using paraffin blocks from 61 patients for immunohistochemical analysis of MTSS1 expression. A subgroup of these tissues was verified by Western blot analysis. MTSS1 protein was expressed in 24 of 61 cases (39.3 %) of tumor tissues, compared to that in 22 of 26 (84.6 %) of non-neoplastic bile duct epithelium and in 26 of 26 (100 %) of adjacent normal liver cells. Loss of MTSS1 expression was associated with lymph node metastases of cholangiocelluarcarcinoma and tumorcellde-differentiation.MTSS1 expression inversely associated with tumor recurrence and overall survival of the patients by univariate and multivariate analyses. MTSS1 expression was significantly decreased in human hilarcholangiocarcinoma and lost MTSS1 expression was associated with pooroverall survival and tumor recurrences in cholangiocarcinoma patients. Thus, MTSS1 expression represents an independent predictor for tumor recurrence and overall survival in patients with cholangiocarcinoma.
File Format	HTM / HTML
ISSN	12194956
Issue Number	4
Volume Number	19
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2013-10-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Bile Duct Neoplasms Metabolism Bile Ducts, Intrahepatic Tumor Markers, Biological Biosynthesis Cholangiocarcinoma Microfilament Proteins Neoplasm Proteins Adult Aged Pathology Chi-square Distribution Female Humans Immunohistochemistry Kaplan-meier Estimate Male Deficiency Middle Aged Prognosis Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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