NDLI: Overexpression of metastasis-associated in colon cancer-1 associated with poor prognosis in patients with esophageal cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhu, Mingchen Xu, Yijun Mao, Xuelian Gao, Yanfang Shao, Lijia Yan, Feng
Description	Country affiliation: China Author Affiliation: Zhu M ( Department of Clinical Laboratory, Jiangsu Cancer Hospital & Nanjing Medical University Cancer Hospital, 42 Baiziting Road, Nanjing, 210009, Jiangsu, China.)
Abstract	Recent studies have shown that expression of metastasis-associated in colon cancer-1(MACC1) is observed in different types of cancer and plays an important role in tumor metastasis. However, the expression of MACC1 and its possible role in esophageal cancer remains unknown. In this study, we determined the expression of MACC1 in esophageal cancer by utilizing immunohistochemistry and analyzed the relationship between the expression and esophageal cancer prognosis. Immunohistochemistry results showed that 47 of 85 cancer lesions (55.2 %) were stained positive, and high expression of MACC1 was correlated with the node metastasis and TNM stage (P < 0.05). The Kaplan-Meier survival curve showed that patients with high MACC1 expression had significantly reduced overall 5-year survival rates (P = 0.004). Cox regression analysis revealed that high expression of MACC1 was associated with increased risk of death (hazard ratio [HR] =2.25) in patients with esophageal cancer. These findings suggested that high expression of MACC1 was correlated with progression and metastasis of esophageal cancer and might serve as a novel prognostic marker for patients with esophageal cancer.
File Format	HTM / HTML
ISSN	12194956
Issue Number	4
Volume Number	19
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2013-10-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Esophageal Neoplasms Metabolism Transcription Factors Biosynthesis Aged Pathology Female Humans Immunohistochemistry Kaplan-meier Estimate Male Middle Aged Neoplasm Metastasis Prognosis Regression Analysis Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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