NDLI: Dynamic accumulation and redistribution of methylmercury in the lens of developing zebrafish embryos and larvae.

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Dynamic accumulation and redistribution of methylmercury in the lens of developing zebrafish embryos and larvae.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Korbas, Malgorzata Krone, Patrick H. Pickering, Ingrid J. George, Graham N.
Description	Country affiliation: Canada Author Affiliation: Korbas M ( Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, SK, S7N 5E2, Canada.)
Abstract	Neurotoxic methylmercury compounds are widespread in the environment and human exposure worries many communities worldwide. Despite numerous studies addressing methylmercury toxicity, the detailed mechanisms underlying its transport and accumulation, especially during early developmental stages, remain unclear. Zebrafish larvae are increasingly used as a model system for studies of vertebrate development and toxicology. Previously, we have identified the lens epithelium as the primary site for cellular mercury accumulation in developing zebrafish larvae (Korbas et al. in Proc Natl Acad Sci USA 105:12108-12112, 2008). Here we present a study on the dynamics of methylmercury accumulation and redistribution in the lens following embryonic and larval exposure to methylmercury L-cysteineate using synchrotron X-ray fluorescence imaging. We observed highly specific accumulation of mercury in the lens that continues well after removal of fish from treatment solutions, thus significantly increasing the post-exposure loading of mercury in the lens. The results indicate that mercury is redistributed from the original target tissue to the eye lens, identifying the developing lens as a major sink for methylmercury in early embryonic and larval stages.
File Format	HTM / HTML
ISSN	09498257
Issue Number	7
Volume Number	15
e-ISSN	14321327
Journal	JBIC Journal of Biological Inorganic Chemistry
Language	English
Publisher	Springer
Publisher Date	2010-09-01
Publisher Place	Germany
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Biochemistry Embryo, Nonmammalian Larva Lens, Crystalline Metabolism Methylmercury Compounds Zebrafish Animals Anatomy & Histology Humans Toxicity Tissue Distribution Water Pollutants, Chemical Physiology Journal Article Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Biochemistry Inorganic Chemistry

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