NDLI: MDM2 gene amplification in colorectal cancer is associated with disease progression at the primary site, but inversely correlated with distant metastasis

Please wait, while we are loading the content...

Year: 2017 Volume: 56

Year: 2016 Volume: 55

Year: 2015 Volume: 54

Year: 2014 Volume: 53

Year: 2013 Volume: 52

Year: 2012 Volume: 51

Year: 2011 Volume: 50

Year: 2010 Volume: 49

Year: 2010 Volume: 49 Issue: 12

Year: 2010 Volume: 49 Issue: 11

Year: 2010 Volume: 49 Issue: 10

Year: 2010 Volume: 49 Issue: 9

Year: 2010 Volume: 49 Issue: 8

Year: 2010 Volume: 49 Issue: 7

MiR-221 and MiR-222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B, CDKNIC and overall survival.

Autoantibodies against stress-induced phosphoprotein-1 as a novel biomarker candidate for ovarian cancer.

Genome-wide analysis of allelic imbalances reveals 4q deletions as a poor prognostic factor and MDM4 amplification at 1q32.1 in hepatoblastoma.

Combined classical cytogenetics and microarray-based genomic copy number analysis reveal frequent 3;5 rearrangements in clear cell renal cell carcinoma.

MDM2 gene amplification in colorectal cancer is associated with disease progression at the primary site, but inversely correlated with distant metastasis

HMGA1 and HMGA2 rearrangements in mass-forming endometriosis.

Noonan syndrome, the SOS1 gene and embryonal rhabdomyosarcoma

High-resolution analysis of genomic alteration on chromosome arm 8p in urothelial carcinoma.

Year: 2010 Volume: 49 Issue: 6

Year: 2010 Volume: 49 Issue: 5

Year: 2010 Volume: 49 Issue: 4

Year: 2010 Volume: 49 Issue: 3

Year: 2010 Volume: 49 Issue: 2

Year: 2010 Volume: 49 Issue: 1

Year: 2009 Volume: 48

Year: 2008 Volume: 47

Year: 2007 Volume: 46

Year: 2006 Volume: 45

Year: 2005 Volume: 44

Year: 2004 Volume: 41

Year: 2004 Volume: 40

Year: 2000 Volume: 27

MDM2 gene amplification in colorectal cancer is associated with disease progression at the primary site, but inversely correlated with distant metastasis

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sugano, Nobuhiro Suda, Tetsuji Godai, Ten-I Tsuchida, Kazuhito Shiozawa, Manabu Sekiguchi, Hironobu Yoshihara, Mitsuyo Matsukuma, Shoichi Sakuma, Yuji Tsuchiya, Eiju Kameda, Yoichi Akaike, Makoto Miyagi, Yohei
Description	Country affiliation: Japan Author Affiliation: Sugano N ( Department of Gastrointestinal Surgery, Kanagawa Cancer Center Hospital, Yokohama, Japan.)
Abstract	MDM2 is a crucial negative regulator of the TP53 tumor suppressor and almost 10% of human tumors exhibit MDM2 amplification. Although TP53 pathway perturbation has been extensively examined in colorectal cancer (CRC), only one previous report has evaluated MDM2 amplification in relation to clinicopathological factors. In that report, MDM2 amplification was shown to be associated with disease progression from Dukes' Stages A to D. In this study, we investigated MDM2 amplification by quantitative PCR and fluorescence in situ hybridization (FISH) together with the SNP309 genotypes, and analyzed the correlations with TP53 and KRAS mutations and clinicopathological features in 211 Japanese CRC patients. MDM2 amplification was detected in 8% of the specimens and its incidence was significantly higher in Dukes' stage C than in the combined earlier Stages A and B (P = 0.025). Unexpectedly, the incidence was significantly decreased in Stage D metastatic disease (P = 0.043). The copy number gain ranged from four to eight copies and was generally concordant with gain of centromere 12 using FISH analysis. Together with the results of centromere 1 FISH and TP53 copy number assessment, the MDM2 increment most likely resulted from chromosome 12 gain. The mechanism of the copy number gain and incidence in Dukes' Stage D differed considerably from the previous report. Ethnic or geographic factors could be responsible for these differences. Several promising therapeutic strategies targeting the TP53-MDM2 system are being developed. Further understanding of the significance of MDM2 and MDM2 amplification in CRC is required to facilitate personalized treatment for CRC patients.© 2010 Wiley-Liss, Inc.
File Format	HTM / HTML
ISSN	10452257
Issue Number	7
Volume Number	49
e-ISSN	10982264
Journal	Genes, Chromosomes and Cancer
Language	English
Publisher	Wiley-Liss
Publisher Date	2010-07-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Molecular Biology Discipline Oncology Colorectal Neoplasms Genetics Pathology Gene Amplification Genes, Ras Genotype Humans Polymerase Chain Reaction Polymorphism, Single Nucleotide Proto-oncogene Proteins C-mdm2 Journal Article
Content Type	Text
Resource Type	Article
Subject	Genetics Cancer Research

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in