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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Arai, Yasuhito Honda, Shohei Haruta, Masayuki Kasai, Fumio Fujiwara, Yuiko Ohshima, Junjiro Sasaki, Fumiaki Nakagawara, Akira Horie, Hiroshi Yamaoka, Hiroyuki Hiyama, Eiso Kaneko, Yasuhiko |
| Description | Country affiliation: Japan Author Affiliation: Arai Y ( Cancer Genomics Project, National Cancer Center Research Institute, Chuo-Ku, Tokyo, Japan.) |
| Abstract | In a single-nucleotide polymorphism array-based analysis of 56 hepatoblastoma (HB) tumors, allelic imbalances were detected in 37 tumors (66%). Chromosome gains were found in 1q (28 tumors), 2q (24), 6p (8), 8q (8), 17q (6), and 20pq (10), and losses in 1p (6), 4q (9), and 16q (4). Fine mapping delineated the shortest overlapping region (SOR) of gains at 1q32.1 (1.3 Mb) and 2q24.2-q24.3 (4.8 Mb), and losses at 4q34.3-q35.2 (8.7 Mb) and 4q32.3 (1.6 Mb). Uniparental disomy of 11pter-11p15.4 (IGF2) and loss of 11pter-p14.1 were found in 11 and 2 tumors, respectively. Expression of HTATIP2 (11p15.1) was absent in 9 of 20 tumors. Amplification was identified in four tumors at 1q32.1, where the candidate oncogene MDM4 is located. In the 4q32.3-SRO, ANXA10S, a variant of the candidate tumor suppressor ANXA10, showed no expression in 19 of 24 tumors. Sequence analysis of ANXA10S identified a missense mutation (E36K, c.106G>A) in a HB cell line. Multivariate analysis revealed that both 4q deletion and RASSF1A methylation (relative risks: 4.21 and 7.55, respectively) are independent prognostic factors. Our results indicate that allelic imbalances and gene expression patterns provide possible diagnostic and prognostic markers, as well as therapeutic targets in a subset of HB. |
| File Format | HTM / HTML |
| ISSN | 10452257 |
| Issue Number | 7 |
| Volume Number | 49 |
| e-ISSN | 10982264 |
| Journal | Genes, Chromosomes and Cancer |
| Language | English |
| Publisher | Wiley-Liss |
| Publisher Date | 2010-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Molecular Biology Discipline Oncology Allelic Imbalance Hepatoblastoma Genetics Acetyltransferases Annexins Clinical Laboratory Techniques Genes Genome Humans Kallikreins Polymorphism, Single Nucleotide Proto-oncogene Proteins Research Sequence Deletion Transcription Factors Tumor Suppressor Proteins Ubiquitin-protein Ligases Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Cancer Research |
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