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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pan, Xin-Min Sun, Rui-Fen Li, Zhao-Hui Guo, Xiao-Min Zhang, Zhen Qin, Hao-Jie Xu, Guo-Hui Gao, Lin-Bo |
| Description | Author Affiliation: Pan XM ( Department of Forensic Pathology, College of Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, 471003, People's Republic of China, mitochondrium@126.com.) |
| Abstract | Growing evidence has indicated that polymorphism present in the miRNA binding site of target gene can alter the ability of miRNAs to bind its target gene and modulate the development and progression of cancer. We aimed to investigate the association between let-7 KRAS rs712 polymorphism and the risk of colorectal cancer (CRC). The let-7 KRAS rs712 was analyzed in a case-control study, including 339 CRC patients and 313 age- and sex-matched controls; the relationship between the polymorphism and the clinicopathological features of CRC was also examined. Individuals carrying the let-7 KRAS rs712 TT genotype and T allele had an increased risk of developing CRC (TT vs. GG, adjusted OR = 2.18; 95% CI, 1.00-4.77; T vs. G, adjusted OR = 1.50; 95% CI, 1.15-1.96). Stratified analyses revealed that CRC patients with the let-7 KRAS rs712 TT genotype were more likely to have clinical stage III or IV disease (OR = 3.29, 95% CI, 1.32-8.20) and distant metastasis (OR = 4.70, 95% CI, 1.81-12.25). These findings provide evidence that the let-7 KRAS rs712 polymorphism may play crucial roles in the etiology of CRC. |
| File Format | HTM / HTML |
| ISSN | 10104283 |
| Issue Number | 1 |
| Volume Number | 35 |
| e-ISSN | 14230380 |
| Journal | Tumor Biology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2014-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Medicine__semicolon__oncology Colorectal Neoplasms Genetics Genetic Predisposition To Disease Micrornas Polymorphism, Single Nucleotide Proto-oncogene Proteins Ras Proteins Aged Alleles Case-control Studies Pathology Female Gene Frequency Genotype Humans Male Middle Aged Neoplasm Staging Odds Ratio Proto-oncogene Proteins P21(ras) Risk Tumor Burden Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Cancer Research |
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