NDLI: Antioxidant properties of MitoTEMPOL and its hydroxylamine.

Please wait, while we are loading the content...

A combination study of spin-trapping, LC/ESR and LC/MS on carbon-centred radicals formed from lipoxygenase-catalysed peroxidation of eicosapentaenoic acid.

Year: 2009 Volume: 43 Issue: Supplementary 1

Year: 2008 Volume: 42

Year: 2007 Volume: 41

Year: 2006 Volume: 40

Year: 2005 Volume: 39

Year: 2003 Volume: 37

Antioxidant properties of MitoTEMPOL and its hydroxylamine.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Trnka, Jan Blaikie, Frances H. Logan, Angela Smith, Robin A. J. Murphy, Michael P.
Description	Country affiliation: United kingdom Author Affiliation: Trnka J ( MRC Dunn Human Nutrition Unit, Cambridge, UK.)
Abstract	Piperidine nitroxides such as TEMPOL have been widely used as antioxidants in vitro and in vivo. MitoTEMPOL is a mitochondria-targeted derivative of TEMPOL designed to protect mitochondria from the oxidative damage that they accumulate, but once there is rapidly reduced to its hydroxylamine, MitoTEMPOL-H. As little is known about the antioxidant efficacy of hydroxylamines, this study has assessed the antioxidant activity of both MitoTEMPOL and MitoTEMPOL-H. The hydroxylamine was more effective at preventing lipid-peroxidation than MitoTEMPOL and decreased oxidative damage to mitochondrial DNA caused by menadione. In contrast to MitoTEMPOL, MitoTEMPOL-H has no superoxide dismutase activity and its antioxidant actions are likely to be mediated by hydrogen atom donation. Therefore, even though MitoTEMPOL is rapidly reduced to MitoTEMPOL-H in cells, it remains an effective antioxidant. Furthermore, as TEMPOL is also reduced to a hydroxylamine in vivo, many of its antioxidant effects may also be mediated by its hydroxylamine.
File Format	HTM / HTML
ISSN	10715762
e-ISSN	10292470
DOI	10.1080/10715760802582183
Journal	Free Radical Research
Issue Number	1
Volume Number	43
Language	English
Publisher	Taylor & Francis
Publisher Date	2009-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Biochemistry Antioxidants Pharmacology Cyclic N-oxides Hydroxylamine Mitochondria, Liver Drug Effects Animals Dna, Mitochondrial Lipid Peroxidation Mice Oxidation-reduction Polymerase Chain Reaction Spin Labels Superoxide Dismutase Metabolism Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Reduction of renal superoxide dismutase in progressive diabetic nephropathy.

Oxidative stress-mediated mitochondrial dysfunction contributes to angiotensin II-induced nonalcoholic fatty liver disease in transgenic Ren2 rats.

Copper, zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide.

The nitroxide tempol has similar antioxidant effects as physiological levels of 17beta-oestradiol in reversing ovariectomy-induced oxidative stress in mice liver and kidney.

Effect of tempol on redox homeostasis and stress tolerance in mimetically aged Drosophila.

EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines.

Antioxidant properties of MitoTEMPOL and its hydroxylamine

Investigation of spin-trapping artifacts formed by the Forrester-Hepburn mechanism.

Quercetin Supplementary is effective in improving mitochondrial dysfunctions induced by 3-nitropropionic acid: Implications in Huntington's disease

Antioxidant properties of MitoTEMPOL and its hydroxylamine.

Similar Documents

Reduction of renal superoxide dismutase in progressive diabetic nephropathy.

Oxidative stress-mediated mitochondrial dysfunction contributes to angiotensin II-induced nonalcoholic fatty liver disease in transgenic Ren2 rats.

Copper, zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide.

The nitroxide tempol has similar antioxidant effects as physiological levels of 17beta-oestradiol in reversing ovariectomy-induced oxidative stress in mice liver and kidney.

Effect of tempol on redox homeostasis and stress tolerance in mimetically aged Drosophila.

EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines.

Antioxidant properties of MitoTEMPOL and its hydroxylamine

Investigation of spin-trapping artifacts formed by the Forrester-Hepburn mechanism.

Quercetin Supplementary is effective in improving mitochondrial dysfunctions induced by 3-nitropropionic acid: Implications in Huntington's disease

Antioxidant properties of MitoTEMPOL and its hydroxylamine.