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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Aksu, Ugur Yanar, Karolin Terzioglu, Duygu Erkol, Tugçe Ece, Evrim Aydin, Seval Uslu, Ezel Çakatay, Ufuk |
| Description | Country affiliation: Turkey Author Affiliation: Aksu U ( Department of Biology, Science Faculty, Zoology Division, Istanbul University, Istanbul, Turkey.) |
| Abstract | We aimed to test our hypothesis that scavenging reactive oxygen species (ROS) with tempol, a membrane permeable antioxidant, affects the type and magnitude of oxidative damage and stress tolerance through mimetic aging process in Drosophila. Drosophila colonies were randomly divided into three groups: (1) no D-galactose, no tempol; (2) D-galactose without tempol; (3) D-galactose, but with tempol. Mimetic aging was induced by d-galactose administration. The tempol-administered flies received tempol at the concentration of 0.2% in addition to d-galactose. Thiobarbituric acid reacting substance (TBARS) concentrations, advanced oxidation protein products (AOPPs), Cu,Zn-superoxide dismutase (Cu,Zn-SOD), sialic acid (SA) were determined. Additionally, stress tolerances were tested. Mimetically aged group without tempol led to a significant decrease in tolerance to heat, cold, and starvation (P < 0.05), but tempol was used for these parameters. The Cu,Zn-SOD activity and SA concentrations were lower in both mimetically aged and tempol-administered Drosophila groups compared to control (P < 0.05), whereas there were no significantly difference between mimetically aged and tempol-administered groups. Mimetically aged group without tempol led to a significant increase in tissue TBARS and AOPPs concentrations (P < 0.05). Coadministration of tempol could prevent these alterations. Scavenging ROS using tempol also restores redox homeostasis in mimetically aged group. Tempol partly restores age-related oxidative injury and increases stress tolerance. |
| File Format | HTM / HTML |
| ISSN | 07394462 |
| Issue Number | 1 |
| Volume Number | 87 |
| e-ISSN | 15206327 |
| Journal | Archives of Insect Biochemistry and Physiology |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2014-09-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Physiology Discipline Biochemistry Discipline Zoology Antioxidants Pharmacology Cyclic N-oxides Drosophila Physiology Homeostasis Oxidative Stress Reactive Oxygen Species Metabolism Aging Animals Galactose Adverse Effects Oxidation-reduction Spin Labels Superoxide Dismutase Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Medicine Biochemistry Insect Science |
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