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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mehrotra, Arpit Sandhir, Rajat |
| Description | Author Affiliation: Sandhir R ( Department of Biochemistry, Panjab University, Chandigarh, India. sandhir@pu.ac.in) |
| Abstract | The study was designed to investigate the beneficial effect of quercetin supplementation in 3-nitropropionic acid (3-NP) induced model of Huntington's disease (HD). HD was induced in rats by administering sub-chronic dose of 3-NP, intraperitoneally, twice daily for 17 days. Quercetin was supplemented at a dose of 25 mg/kg body weight by oral gavage for 21 days. At the end of treatment, mitochondrial bioenergetics, mitochondrial swelling, oxidative stress, neurobehavioral deficits and histopathological changes were analyzed. Quercetin supplementation was able to reverse 3-NP induced inhibition of respiratory chain complexes, restore ATP levels, attenuate mitochondrial oxidative stress in terms of lipid peroxidation and prevent mitochondrial swelling. Quercetin administration also restored the activities of superoxide dismutase and catalase along with thiol content in 3-NP treated animals. Beneficial effect of quercetin administration was observed on 3-NP induced motor deficits analyzed by narrow beam walk and footprint analysis. Histopathological analysis of 3-NP treated rats revealed pyknotic nuclei and astrogliosis in striatum, which were reduced or absent in quercetin supplemented animals. Altogether, our results show that quercetin supplementation to 3-NP induced HD animals ameliorated mitochondrial dysfunctions, oxidative stress and neurobehavioral deficits in rats showing potential of this flavonoid in maintaining mitochondrial functions, suggesting a putative role of quercetin in HD management. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 3 |
| Volume Number | 1832 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Dietary Supplements Huntington Disease Metabolism Mitochondria Drug Effects Quercetin Pharmacology Animals Antioxidants Administration & Dosage Catalase Corpus Striatum Pathology Electron Transport Chain Complex Proteins Chemically Induced Physiopathology Lipid Peroxidation Mitochondrial Swelling Motor Activity Nitro Compounds Oxidation-Reduction Propionates Rats, Wistar Sulfhydryl Compounds Superoxide Dismutase Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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