NDLI: Mepivacaine-induced contraction is attenuated by endothelial nitric oxide release in isolated rat aorta.

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Mepivacaine-induced contraction is attenuated by endothelial nitric oxide release in isolated rat aorta.

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Mepivacaine-induced contraction is attenuated by endothelial nitric oxide release in isolated rat aorta.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sung, Hui-Jin Choi, Mun-Jeoung Ok, Seong-Ho Lee, Soo Hee Hwang, Il Jeong Kim, Hee Sook Chang, Ki Churl Shin, Il-Woo Lee, Heon-Keun Park, Kyeong-Eon Chung, Young-Kyun Sohn, Ju-Tae
Description	Author Affiliation: Sung HJ ( Department of Anesthesiology, Charmjoeun Obstetrics and Gynecology Clinic, Jinju, Korea.)
Abstract	Mepivacaine is an aminoamide-linked local anesthetic with an intermediate duration that intrinsically produces vasoconstriction both in vivo and in vitro. The aims of this in-vitro study were to examine the direct effect of mepivacaine in isolated rat aortic rings and to determine the associated cellular mechanism with a particular focus on endothelium-derived vasodilators, which modulate vascular tone. In the aortic rings with or without endothelium, cumulative mepivacaine concentration-response curves were generated in the presence or absence of the following antagonists: N(ω)-nitro-L-arginine methyl ester [L-NAME], indomethacin, fluconazole, methylene blue, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one [ODQ], verapamil, and calcium-free Krebs solution. Mepivacaine produced vasoconstriction at low concentrations (1 × 10(-3) and 3 × 10(-3) mol/L) followed by vasodilation at a high concentration (1 × 10(-2) mol/L). The mepivacaine-induced contraction was higher in endothelium-denuded aortae than in endothelium-intact aortae. Pretreatment with L-NAME, ODQ, and methylene blue enhanced mepivacaine-induced contraction in the endothelium-intact rings, whereas fluconazole had no effect. Indomethacin slightly attenuated mepivacaine-induced contraction, whereas verapamil and calcium-free Krebs solution more strongly attenuated this contraction. The vasoconstriction induced by mepivacaine is attenuated mainly by the endothelial nitric oxide - cyclic guanosine monophosphate pathway. In addition, mepivacaine-induced contraction involves cyclooxygenase pathway activation and extracellular calcium influx via voltage-operated calcium channels.
File Format	HTM / HTML
ISSN	00084212
e-ISSN	12057541
Journal	Canadian Journal of Physiology and Pharmacology
Issue Number	7
Volume Number	90
Language	English
Publisher	Canadian Science Publishing
Publisher Date	2012-07-01
Publisher Place	Canada
Access Restriction	Open
Subject Keyword	Discipline Physiology Discipline Pharmacology Anesthetics, Local Pharmacology Aorta Drug Effects Endothelium, Vascular Mepivacaine Muscle, Smooth, Vascular Vasoconstriction Animals Metabolism Calcium Calcium Channels Cells, Cultured Cyclic Gmp Human Umbilical Vein Endothelial Cells Muscle Contraction Nitric Oxide Prostaglandin-endoperoxide Synthases Rats, Sprague-dawley Vasodilation Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Pharmacology

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