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A study about drug combination therapy of Schisandra sphenanthera extract and Rapamycin in healthy subjects.

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A study about drug combination therapy of Schisandra sphenanthera extract and Rapamycin in healthy subjects.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Ruidong Guo, Wenyuan Fu, Zhiren Ding, Guoshan Wang, Zhengxin Fu, Hong
Description	Country affiliation: China Author Affiliation: Li R ( Department of Organ Transplantation, Changzheng Hospital, The Second Military Medical University, Shanghai, China. liruidong2010@gmail.com)
Abstract	To assess the effect of the drug combination of Schisandra sphenanthera extract (SchE) and Rapamycin (RAPA), 18 healthy subjects were given oral treatments of RAPA alone and with SchE. Pharmacokinetic investigations and indexes of hepatic and renal functions, as well as other indices of oral RAPA administration (2 mg), were performed both before and after the SchE treatment period. Whole-blood RAPA concentrations were determined by enzyme-linked immunosorbent assay. The research found that the mean whole-blood RAPA AUC(0-∞), C(max), and t(max) increased almost 2-, 2.1-, and 1.3-fold, respectively, and CL/F (-38.0%) decreased almost 1.6-fold in these subjects when RAPA was administered with SchE compared with oral RAPA administered alone. The results of this study proved that SchE can increase the oral bioavailability of RAPA and will add important information to the interaction area between drugs and herbal products.
File Format	HTM / HTML
ISSN	00084212
e-ISSN	12057541
Journal	Canadian Journal of Physiology and Pharmacology
Issue Number	7
Volume Number	90
Language	English
Publisher	Canadian Science Publishing
Publisher Date	2012-07-01
Publisher Place	Canada
Access Restriction	Open
Subject Keyword	Discipline Physiology Discipline Pharmacology Herb-drug Interactions Plant Extracts Pharmacology Schisandra Chemistry Sirolimus Administration, Oral Area Under Curve Biological Availability Drug Therapy, Combination Blood Pharmacokinetics
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Pharmacology

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