NDLI: Attenuation of endothelin-1-induced PKB and ERK1/2 signaling, as well as Egr-1 expression, by curcumin in A-10 vascular smooth muscle cells.

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Attenuation of endothelin-1-induced PKB and ERK1/2 signaling, as well as Egr-1 expression, by curcumin in A-10 vascular smooth muscle cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kapakos, Georgia Youreva, Viktoria Srivastava, Ashok K.
Description	Country affiliation: Canada Author Affiliation: Kapakos G ( Laboratory of Cell Signaling, Research Center of Centre Hospitalier de l'Université de Montréal - Angus Campus, Department of Medicine, Université de Montréal, QC, Canada.)
Abstract	Endothelin-1 (ET-1) is implicated in the pathogenesis of vascular abnormalities through the hyperactivation of growth promoting pathways, including protein kinase B (PKB) and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling. ET-1 has been shown to elicit its responses through the generation of reactive oxygen species (ROS). Curcumin, the main constituent of the spice turmeric, exhibits cardio-protective, anti-proliferative, and antioxidant properties; however, the precise molecular mechanism of its action is unclear. Therefore, in the present study, we investigated the effects of curcumin on ET-1-induced PKB and ERK1/2 signaling, as well as insulin-like growth factor type receptor (IGF-1R) phosphorylation. Curcumin dose-dependently inhibited ET-1-induced phosphorylation of PKB, ERK1/2, c-Raf, and insulin-like growth factor type 1 receptor (IGF-1R), in vascular smooth muscle cells (VSMC). Furthermore, curcumin also attenuated ET-1-induced expression of early growth response (Egr)-1, a transcription factor downstream of ERK1/2 that plays a regulatory role in several cardiovascular pathological processes. In conclusion, these data demonstrate that curcumin is a potent inhibitor of ET-1-induced mitogenic and proliferative signaling events in VSMC and suggest that the ability of curcumin to attenuate these events may contribute as a potential mechanism for its cardiovascular protective response.
File Format	HTM / HTML
ISSN	00084212
e-ISSN	12057541
Journal	Canadian Journal of Physiology and Pharmacology
Issue Number	9
Volume Number	90
Language	English
Publisher	Canadian Science Publishing
Publisher Date	2012-09-01
Publisher Place	Canada
Access Restriction	Open
Subject Keyword	Discipline Physiology Discipline Pharmacology Aorta, Thoracic Drug Effects Curcumin Pharmacology Early Growth Response Protein 1 Biosynthesis Endothelin-1 Map Kinase Signaling System Muscle, Smooth, Vascular Proto-oncogene Proteins C-akt Metabolism Animals Cytology Embryology Enzymology Apoptosis Cell Culture Techniques Cell Line Cell Proliferation Down-regulation Phosphorylation Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical) Pharmacology

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