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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bacová, Barbara Radosinská, Jana Viczenczová, Csilla Knezl, Vladimír Dosenko, Victor Benova, Tamara Navarová, Jana Gonçalvesová, Eva Van Rooyen, Jacques Weismann, Peter Slezák, Jan Tribulová, Narcis |
| Description | Country affiliation: Slovakia Author Affiliation: Bacová B ( Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Dúbravská, Slovakia.) |
| Abstract | The purpose of this study was to test our hypothesis that red palm oil (RPO) intake may affect abnormalities of myocardial connexin-43 (Cx43) and protein kinase Cε (PKCε) signaling, and consequently the propensity of the spontaneously hypertensive rat heart (SHR) heart to arrhythmias. SHR and Wistar-Kyoto (WKY) rats fed a standard rat chow plus red palm oil (200 µL/day) for 5 weeks were compared with untreated rats. Cytosolic but not particulate PKCε expression as well as Cx43-mRNA, total Cx43 proteins, and its phoshorylated forms were increased, and disordered localization of Cx43 was attenuated in the left ventricle of RPO-fed SHR compared with untreated rats. These alterations were associated with suppression of early post-ischemic-reperfusion-related ventricular tachycardia and electrically inducible ventricular fibrillation. However, the treatment dose of RPO caused down-regulation of myocardial Cx43, but did not alter its cell membrane distribution or overall PKCε expression in WKY rats. It was, however, associated with poor arrhythmia protection, suggesting overdosing. Results indicate that SHR benefit from RPO intake, particularly because of its apparent anti-arrhythmic effects. This protection can be, in part, attributed to the preservation of cell-to-cell communication via up-regulation of myocardial Cx43, but not with PKCε activation. |
| File Format | HTM / HTML |
| ISSN | 00084212 |
| e-ISSN | 12057541 |
| Journal | Canadian Journal of Physiology and Pharmacology |
| Issue Number | 9 |
| Volume Number | 90 |
| Language | English |
| Publisher | Canadian Science Publishing |
| Publisher Date | 2012-09-01 |
| Publisher Place | Canada |
| Access Restriction | Open |
| Subject Keyword | Discipline Physiology Discipline Pharmacology Anti-arrhythmia Agents Therapeutic Use Arrhythmias, Cardiac Prevention & Control Connexin 43 Biosynthesis Hypertension Metabolism Myocardium Plant Oils Animals Administration & Dosage Pharmacology Etiology Blood Pressure Physiology Blotting, Western Complications Drug Therapy Enzymology In Vitro Techniques Rats, Inbred Shr Rats, Inbred Wky Real-time Polymerase Chain Reaction Up-regulation Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Pharmacology |
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