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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kuruppu, Anchala I. Zhang, Lei Collins, Hilary Turyanska, Lyudmila Thomas, Neil R. Bradshaw, Tracey D. |
| Description | Country affiliation: United kingdom Author Affiliation: Kuruppu AI ( Centre for Biomolecular Sciences, School of Pharmacy, The University of Nottingham, Nottingham, NG7 2RD, UK.); Zhang L ( Centre for Biomolecular Sciences, School of Chemistry, The University of Nottingham, Nottingham, NG7 2RD, UK.); Collins H ( Centre for Biomolecular Sciences, School of Pharmacy, The University of Nottingham, Nottingham, NG7 2RD, UK.); Turyanska L ( School of Physics and Astronomy, The University of Nottingham, Nottingham, NG7 2RD, UK.); Thomas NR ( Centre for Biomolecular Sciences, School of Chemistry, The University of Nottingham, Nottingham, NG7 2RD, UK.); Bradshaw TD ( Centre for Biomolecular Sciences, School of Pharmacy, The University of Nottingham, Nottingham, NG7 2RD, UK.) |
| Abstract | Anticancer drug Gefitinib encapsulated within human heavy chain apoferritin by diffusion allows pH-controlled sustained release of cargo. The combination of increased cellular uptake, and potent and enhanced antitumor activity against the HER2 overexpressing SKBR3 cell line compared to Gefitinib alone, makes it a promising carrier for delivery of drugs to tumor sites. |
| File Format | HTM / HTML |
| ISSN | 21922640 |
| Issue Number | 18 |
| Volume Number | 4 |
| e-ISSN | 21922659 |
| Journal | Advanced Healthcare Materials |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2015-12-30 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biomedical Engineering Apoferritins Metabolism Drug Delivery Systems Methods Protein Kinase Inhibitors Pharmacology Quinazolines Cell Line, Tumor Endocytosis Drug Effects Humans Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Biomedical Engineering Pharmaceutical Science |
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