NDLI: Assessing risk for development of diabetes in young adults.

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Assessing risk for development of diabetes in young adults.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mainous, Arch G. Diaz, Vanessa A. Everett, Charles J.
Description	Country affiliation: Seychelles Author Affiliation: Mainous AG ( Department of Family Medicine, Medical University of South Carolina, Charleston, SC.)
Abstract	PURPOSE: The prevalence of diabetes is increasing to epidemic levels. A multivariable risk score for the development of diabetes has been shown to be predictive for middle-aged adults; however, it is unclear how well it performs in a younger adult population. The purpose of this study was to evaluate a preexisting multivariable risk score for the development of diabetes in a young adult cohort. METHODS: We analyzed the Coronary Artery Risk Development in Young Adults (CARDIA), a population-based observational study of participants aged 18 to 30 years recruited in 1985-1986. We observed individuals without diabetes at baseline for 10 years for the development of diabetes (n = 2,543). We computed receiver operating characteristic (ROC) curves for a diabetes risk score composed of the following 6 variables: elevated blood pressure, low high-density lipoprotein cholesterol levels, high triglyceride levels, body mass index, large waist circumference, and hyperglycemia. RESULTS: The area under the ROC curve was .70 in this population, which was less than the .78 previously found among middle-aged adults. BMI alone (.67) was not significantly different from the risk score. Blacks (.72; 95% CI, .69-.74) and whites (.68; 95% CI, .66-.71) do not significantly differ in the area under the ROC curve for the risk score; however, the area under the ROC curve for BMI is significantly larger for blacks (.69; 95% CI, .66-.72) than for whites (.63; 95% CI, .60-.65). CONCLUSION: An established risk score for the development of diabetes among middle-aged persons has limited utility in a younger population. Future research needs to focus on identifying novel factors that may improve the risk stratification for diabetes development among young adults.
File Format	HTM / HTML
ISSN	15441709
e-ISSN	15441717
Journal	The Annals of Family Medicine
Issue Number	5
Volume Number	5
Language	English
Publisher	Annals of Family Medicine Inc
Publisher Date	2007-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Family Medicine Diabetes Mellitus Diagnosis Adolescent Body Mass Index Cohort Studies Continental Population Groups Genetics Genetic Predisposition To Disease Multivariate Analysis Risk Assessment Risk Factors Sensitivity And Specificity Research Support, N.i.h., Extramural Research Support, U.s. Gov't, P.h.s. Validation Studies
Content Type	Text
Resource Type	Article
Subject	Family Practice

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