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Year: 2008 Volume: 106 Issue: 2

Year: 2008 Volume: 106 Issue: 1

Year: 2008 Volume: 105

Year: 2007 Volume: 103

Histological features and management of a mandibular Gorham disease: a case report and review of maxillofacial cases in the literature.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Escande, Catherine Schouman, Thomas Françoise, Gruffaz Haroche, Julien Ménard, Philippe Piette, Jean-Charles Bertrand, Jacques-Charles Ruhin-Poncet, Blandine
Description	Country affiliation: France Author Affiliation: Escande C ( Oral and Maxillofacial Surgery Department, Pitié-Salpêtrière University Hospital, Pierre et Marie Curie-Paris6 University, Paris, France.)
Abstract	Gorham disease (GD) is a rare osteolysis without sex, race, or age predilection, affecting bones in different regions. Based on clinical, histological, and molecular features, diagnosis is difficult and required exclusion of neoplastic, inflammatory, infectious, and endocrinologic disease. Etiology is still unknown. We report the case of a 36-year-old man suffering from severe progressive osteolysis located at the mandible. Histology showed massive osteolysis without malignant cells. Immunohistochemistry revealed thin-walled vessels and lymphatic ducts. These investigations lead to diagnosis of GD. Radical surgical treatment was followed by bisphophonate therapy. Recurrence occurred 4 months after surgery and alphaa-interferon therapy permitted remission. To support this case report, we reviewed the 41 maxillofacial cases published in the literature since 1928. Jaw is the main location; histology mostly shows hemangioma-like proliferation. Immune disorders are usually advanced as a cause although physiopathology is unknown. Therefore, appropriate treatment is controversial. Antiosteoclastic drugs are usually proposed in addition to surgery, but immunomodulating drugs and radiation therapy should also be considered in the treatment.
File Format	HTM / HTML
ISSN	10792104
Issue Number	3
Volume Number	106
e-ISSN	1528395X
Journal	Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Language	English
Publisher	Elsevier
Publisher Date	2008-09-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Dentistry Discipline General Surgery Mandibular Diseases Pathology Osteolysis, Essential Adult Bone Density Conservation Agents Therapeutic Use Diphosphonates Humans Ki-67 Antigen Analysis Male Drug Therapy Surgery Radiography Remission Induction Case Reports Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Case study Article
Subject	Dentistry Oral Surgery Otorhinolaryngology Surgery

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Histological features and management of a mandibular Gorham disease: a case report and review of maxillofacial cases in the literature.

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