NDLI: Normal serum bone markers in bisphosphonate-induced osteonecrosis of the jaws.

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Year: 2008 Volume: 106 Issue: 2

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Year: 2008 Volume: 105

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Normal serum bone markers in bisphosphonate-induced osteonecrosis of the jaws.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lehrer, Steven Montazem, André Ramanathan, Lakshmi Pessin-Minsley, Melissa Pfail, John Stock, Richard G. Kogan, Rita
Description	Country affiliation: United States Author Affiliation: Lehrer S ( Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA. stevenlehrer@hotmail.com)
Abstract	We obtained serum bone markers and other relevant endocrine assays on 5 patients with osteonecrosis of the jaw (ONJ). The assays were C-telopeptide, N-telopeptide, bone-specific alkaline phosphatase, osteocalcin, intact parathyroid hormone, T3, T4, TSH, and Vitamin D 25 hydroxy. Diagnostic criteria for ONJ were those formulated by the American Association of Oral and Maxillofacial Surgeons. Four of our patients were women. Two had metastatic breast cancer and had been treated with zoledronic acid; one had also received pamidronate. Two others had osteoporosis and had been treated with daily alendronate. One man had metastatic prostate cancer treated with zoledronic acid. All patients had been withdrawn from bisphosphonate for at least 6 months. None were taking or had taken corticosteroids. None of the lesions had shown any significant healing and all were still causing the patients considerable distress. Yet the bone markers were within the normal range as measured in our laboratory, except for intact parathyroid hormone, which was slightly elevated in one case of metastatic breast cancer (177 pg/mL). Because the jaws have a greater blood supply than other bones, and a high bone turnover rate, bisphosphonates are highly concentrated in the jaws. This anatomic concentration of bisphosphonates might cause bisphosphonate-osteonecrosis to be manifested exclusively in the jaws and is consistent with our finding of normal serum bone markers in ONJ patients.
File Format	HTM / HTML
ISSN	10792104
Issue Number	3
Volume Number	106
e-ISSN	1528395X
Journal	Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Language	English
Publisher	Elsevier
Publisher Date	2008-09-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Dentistry Discipline General Surgery Bone Density Conservation Agents Adverse Effects Diphosphonates Jaw Diseases Blood Osteonecrosis 25-hydroxyvitamin D 2 Alkaline Phosphatase Bone Neoplasms Drug Therapy Breast Neoplasms Collagen Type I Female Humans Complications Male Osteocalcin Chemically Induced Osteoporosis, Postmenopausal Parathyroid Hormone Peptides Prostatic Neoplasms Journal Article
Content Type	Text
Resource Type	Article
Subject	Dentistry Oral Surgery Otorhinolaryngology Surgery

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