NDLI: Homeobox genes in normal and abnormal vasculogenesis.

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Homeobox genes in normal and abnormal vasculogenesis.

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Homeobox genes in normal and abnormal vasculogenesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cantile, M. Schiavo, G. Terracciano, L. Cillo, C.
Description	Country affiliation: Italy Author Affiliation: Cantile M ( Department of Clinical and Experimental Medicine, Federico II University Medical School, Naples, Italy.)
Abstract	Homeobox containing genes are a family of transcription factors regulating normal development and controlling primary cellular processes (cell identity, cell division and differentiation) recently enriched by the discovery of their interaction with miRNAs and ncRNAs. Class I human homeobox genes (HOX genes) are characterized by a unique genomic network organization: four compact chromosomal loci where 39 sequence corresponding genes can be aligned with each other in 13 antero-posterior paralogous groups. The cardiovascular system is the first mesoderm organ-system to be generated during embryonic development; subsequently it generates the blood and lymphatic vascular systems. Cardiovascular remodelling is involved through homeobox gene regulation and deregulation in adult physiology (menstrual cycle and wound healing) and pathology (atherosclerosis, arterial restenosis, tumour angiogenesis and lymphangiogenesis). Understanding the role played by homeobox genes in endothelial and smooth muscle cell phenotype determination will be crucial in identifying the molecular processes involved in vascular cell differentiation, as well as to support future therapeutic strategies. We report here on the current knowledge of the role played by homeobox genes in normal and abnormal vasculogenesis and postulate a common molecular mechanism accounting for the involvement of homeobox genes in the regulation of the nuclear export of specific transcripts potentially capable of generating endothelial phenotype modification involved in new vessel formation.
File Format	HTM / HTML
ISSN	09394753
Issue Number	10
Volume Number	18
e-ISSN	15903729
Journal	Nutrition, Metabolism and Cardiovascular Diseases
Language	English
Publisher	Elsevier
Publisher Date	2008-12-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Metabolism Discipline Cardiology Discipline Vascular Diseases Discipline Nutritional Sciences Genes, Homeobox Physiology Neovascularization, Pathologic Etiology Neovascularization, Physiologic Animals Eukaryotic Initiation Factor-4e Homeodomain Proteins Humans Genetics Rna, Small Interfering Therapeutic Use Transcription Factors Tumor Suppressor Proteins Journal Article Research Support, Non-u.s. Gov't Review
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Cardiology and Cardiovascular Medicine

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