NDLI: Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention.

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Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention.

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Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Warensjö, Eva Risérus, Ulf Gustafsson, Inga-Britt Mohsen, Rawya Cederholm, Tommy Vessby, Bengt
Description	Country affiliation: Sweden Author Affiliation: Warensjö E ( Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.)
Abstract	BACKGROUND AND AIMS: Direct measurement of desaturase activities are difficult to obtain in humans. Consequently, surrogate measures of desaturase activity (estimated desaturase activities) have been frequently used in observational studies, and estimated Delta(9)- (or stearoyl-CoA-desaturase (SCD)), Delta(6)- and Delta(5)-desaturase activities have been associated with cardiometabolic disease. Data on how the markers of desaturase activities are modified by changes in dietary fat quality are lacking and therefore warrant examination. METHODS AND RESULTS: In a two-period (three weeks) strictly controlled cross-over study, 20 subjects (six women and 14 men) consumed a diet high in saturated fat (SAT-diet) and a rapeseed oil diet (RO-diet), rich in oleic acid (OA), linoleic acid (LA) and alpha-linolenic acid (ALA). Estimated desaturase activities were calculated as precursor to product FA ratios in serum cholesteryl esters and phospholipids. The estimated SCD [16:1 n-7/16:0] and Delta(6)-desaturase [20:3 n-6/18:2 n-6] was significantly higher while Delta(5)-desaturase [20:4 n-6/20:3 n-6] was significantly lower in the SAT-diet (P<0.001 for all), compared to the RO-diet. The serum proportions of palmitic, stearic, palmitoleic and dihomo-gamma-linolenic acids were significantly higher in the SAT-diet while the proportions of LA and ALA were significantly higher in the RO-diet. CONCLUSION: This is the first study to demonstrate that surrogate measures of desaturase activities change as a consequence of an alteration in dietary fat quality. Both the [16:1/16:0]-ratio and 16:1 seem to reflect changes in saturated fat intake and may be useful markers of saturated fat intake in Western countries.
File Format	HTM / HTML
ISSN	09394753
Issue Number	10
Volume Number	18
e-ISSN	15903729
Journal	Nutrition, Metabolism and Cardiovascular Diseases
Language	English
Publisher	Elsevier
Publisher Date	2008-12-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Metabolism Discipline Cardiology Discipline Vascular Diseases Discipline Nutritional Sciences Dietary Fats, Unsaturated Administration & Dosage Dietary Fats Fatty Acid Desaturases Metabolism Adult Aged Cross-over Studies Fatty Acids Blood Fatty Acids, Monounsaturated Female Humans Linoleic Acid Male Middle Aged Oleic Acid Plant Oils Alpha-linolenic Acid Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Endocrinology, Diabetes and Metabolism Cardiology and Cardiovascular Medicine

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