NDLI: Comparative effects of well-balanced diets enriched in -linolenic or linoleic acids on LC-PUFA metabolism in rat tissues.

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Comparative effects of well-balanced diets enriched in -linolenic or linoleic acids on LC-PUFA metabolism in rat tissues.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Blanchard, H. Pédrono, F. Boulier-Monthéan, N. Catheline, D. Rioux, V. Legrand, P.
Description	Country affiliation: France Author Affiliation: Blanchard H ( Laboratoire de Biochimie et Nutrition Humaine, INRA USC 2012, Agrocampus Ouest, Rennes, France.)
Abstract	The intake of the essential fatty acid precursor -linolenic acid (ALA) contributes to ensure adequate n-3 long-chain polyunsaturated fatty acid (LC-PUFA) bioavailability. Conversely, linoleic acid (LA) intake may compromise tissue n-3 PUFA status as its conversion to n-6 LC-PUFA shares a common enzymatic pathway with the n-3 family. This study aimed to measure dietary ALA and LA contribution to LC-PUFA biosynthesis and tissue composition. Rats were fed with control or experimental diets moderately enriched in ALA or LA for 8 weeks. Liver Δ6- and Δ5-desaturases were analyzed and FA composition was determined in tissues (red blood cells, liver, brain and heart). Hepatic Δ6-desaturase activity was activated with both diets, and Δ5-desaturase activity only with the ALA diet. The ALA diet led to higher n-3 LC-PUFA composition, including DHA in brain and heart. The LA diet reduced n-3 content in blood, liver and heart, without impacting n-6 LC-PUFA composition. At levels relevant with human nutrition, increasing dietary ALA and reducing LA intake were both beneficial in increasing n-3 LC-PUFA bioavailability in tissues.
File Format	HTM / HTML
ISSN	09523278
Issue Number	5
Volume Number	88
e-ISSN	15322823
Journal	Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Language	English
Publisher	Elsevier
Publisher Date	2013-05-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Endocrinology Fatty Acids, Unsaturated Metabolism Linoleic Acids Administration & Dosage Alpha-linolenic Acid Animals Diet Fatty Acid Desaturases Heart Organ Specificity Rats Stearoyl-coa Desaturase Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cell Biology Clinical Biochemistry

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Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters.

Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels.

Cicer arietinum phytosome ameliorates hepatosteatosis via downregulation of fatty acid synthase and stearoyl-CoA desaturase 1 in rats

Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids.

Stearoyl-CoA Desaturase Activity and Gene Expression in the Adipose Tissue of Buffalo Bulls Was Unaffected by Diets with Different Fat Content and Fatty Acid Profile

Total dietary fat and fatty acid content modifies plasma phospholipid fatty acids, desaturase activity indices, and urinary prostaglandin E in women.

Dietary oils and FADS1-FADS2 genetic variants modulate [13C] -linolenic acid metabolism and plasma fatty acid composition.

Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet

Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention.

Comparative effects of well-balanced diets enriched in -linolenic or linoleic acids on LC-PUFA metabolism in rat tissues.

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