NDLI: Gold nanoparticle interactions in human blood: a model evaluation.

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Gold nanoparticle interactions in human blood: a model evaluation.

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Gold nanoparticle interactions in human blood: a model evaluation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ajdari, Niloofar Vyas, Cian Bogan, Stephanie L. Lwaleed, Bashir A. Cousins, Brian G.
Description	Country affiliation: United kingdom Author Affiliation: Ajdari N ( Department of Mechanical Engineering, Imperial College London, U.K.); Vyas C ( School of Mechanical, Aerospace & Civil Engineering, University of Manchester, U.K.); Bogan SL ( Centre for Nanotechnology & Regenerative Medicine, University College London, U.K.); Lwaleed BA ( Division of Surgery & Interventional Science, University College London, U.K.); Cousins BG ( Centre for Nanotechnology & Regenerative Medicine, University College London, U.K.. Electronic address: brian.cousins@ucl.ac.uk.)
Abstract	In this study, we investigated gold nanoparticle (AuNP) interactions in blood using thromboelastography as a rapid screening tool to monitor their influence on blood coagulation. 1.2 nM colloidal AuNPs ranging from 12 to 85 nm have no effect in the blood, however, 5 nM AuNPs demonstrate pro-thrombogenic concentration dependent effects with a reduction in clot formation. Size effects exhibit a non-linear trend with 45 and 85 nm particles resulting in a faster pro-thrombotic response. Clot strength decreased with AuNP size with the greatest reduction with 28 nm particles. We assessed AuNP interactions in the blood focusing on their biological activity. AuNP-RGD possessed pro-coagulant activities, while PEG-thiol, human fibrinogen and clopidogrel prevented blood clot formation and influenced platelet activity, and were more efficient when bound to nanocarriers than unbound ligands. Such tests could fill the knowledge gaps in thrombogenicity of NPs between in vitro test methods and predict in vivo haemocompatibility.
File Format	HTM / HTML
ISSN	15499634
Journal	Nanomedicine: Nanotechnology, Biology and Medicine
e-ISSN	15499642
Language	English
Publisher	Elsevier
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nanotechnology Discipline Biotechnology
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Medicine Molecular Medicine Bioengineering Biomedical Engineering Pharmaceutical Science

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