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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ribeiro-Samy, Silvina Silva, Nuno A. Correlo, Vitor M. Fraga, Joana S. Pinto, Luísa Teixeira-Castro, Andreia Leite-Almeida, Hugo Almeida, Armando Gimble, Jeffrey M. Sousa, Nuno Salgado, António J. Reis, Rui L. |
| Description | Country affiliation: Portugal Author Affiliation: Ribeiro-Samy S ( 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909, Taipas, Guimarães, Portugal) |
| Abstract | Spinal cord injury (SCI) leads to devastating neurological deficits. Several tissue engineering (TE)-based approaches have been investigated for repairing this condition. Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB-HV) is found to be particularly attractive for TE applications due to its properties, such as biodegradability, biocompatibility, thermoplasticity and piezoelectricity. Hence, this report addresses the development and characterization of PHB-HV-based 3D scaffolds, produced by freeze-drying, aimed to SCI treatment. The obtained scaffolds reveal an anisotropic morphology with a fully interconnected network of pores. In vitro studies demonstrate a lack of cytotoxic effect of PHB-HV scaffolds. Direct contact assays also reveal their ability to support the culture of CNS-derived cells and mesenchymal-like stem cells from different sources. Finally, histocompatibility studies show that PHB-HV scaffolds are well tolerated by the host tissue, and do not negatively impact the left hindlimb locomotor function recovery. Therefore results herein presented suggest that PHB-HV scaffolds may be suitable for SCI treatment. |
| File Format | HTM / HTML |
| ISSN | 16165187 |
| Issue Number | 11 |
| Volume Number | 13 |
| e-ISSN | 16165195 |
| Journal | Macromolecular Bioscience |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2013-11-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Biocompatible Materials Chemistry Cell- And Tissue-based Therapy Methods Polyesters Spinal Cord Injuries Surgery Tissue Engineering Animals Astrocytes Cytology Drug Effects Pharmacology Cell Proliferation Cell Survival Freeze Drying Hippocampus Human Umbilical Vein Endothelial Cells Humans Materials Testing Mesenchymal Stromal Cells Microscopy, Electron, Scanning Neurons Porosity Primary Cell Culture Rats Rats, Wistar Recovery Of Function Pathology Tissue Scaffolds Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Materials Chemistry Biomaterials Bioengineering Biotechnology Polymers and Plastics |
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