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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Peniche, Hazel Reyes-Ortega, Felisa Aguilar, María R. Rodríguez, Gema Abradelo, Cristina García-Fernández, Luis Peniche, Carlos San Román, Julio |
| Description | Country affiliation: Cuba Author Affiliation: Peniche H ( Centro de Biomateriales, Universidad de La Habana, 10400, Havana, Cuba.) |
| Abstract | Thermosensitive macroporous scaffolds of poly(N-isopropylacrylamide) (polyNIPA) loaded with chitosan/bemiparin nanoparticles are prepared by the free radical polymerization in cryogenic conditions. Chitosan/bemiparin nanoparticles of 102 ± 6.5 nm diameter are prepared by complex coacervation and loaded into polyNIPA cryogels. SEM image reveal the highly porous structure of cryogels and the integration of nanoparticles into the macroporous system. Volume phase transition temperature (VPT) and total freezing water content of cryogels are established by differential scanning calorimetry, and their porosity is determined by image-NMR. Swelling of cryogels (above and below the VPT) is highly dependent on nanoparticles concentration. In vitro release profile of bemiparin from cryogel is highly modulated by the presence of chitosan. Bemiparin released from nanoparticles preserves its biological activity, as shown by the BaF32 cell proliferation assay. Cryogels are not cytotoxic for the human fibroblast cells and present excellent properties for application on tissue engineering and controlled release of heparin. |
| File Format | HTM / HTML |
| ISSN | 16165187 |
| Issue Number | 11 |
| Volume Number | 13 |
| e-ISSN | 16165195 |
| Journal | Macromolecular Bioscience |
| Language | English |
| Publisher | Wiley-VCH |
| Publisher Date | 2013-11-01 |
| Publisher Place | Germany |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Acrylic Resins Chemistry Chitosan Cryogels Delayed-action Preparations Heparin, Low-molecular-weight Nanoparticles Pharmacology B-lymphocytes Cytology Drug Effects Biocompatible Materials Cell Line Cell Proliferation Fibroblasts Humans Kinetics Microscopy, Electron, Scanning Particle Size Polymerization Porosity Temperature Tissue Engineering Tissue Scaffolds Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Materials Chemistry Biomaterials Bioengineering Biotechnology Polymers and Plastics |
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