| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Sasaki, Shunsuke Daimon, Masao Kawata, Takayuki Miyazaki, Sakiko Ichikawa, Ryoko Maruyama, Masaki Chiang, Shuo-Ju Mahara, Keitaro Watanabe, Hiroyuki Sumiyoshi, Tetsuya Tomoike, Hitonobu Daida, Hiroyuki |
| Description |
Country affiliation: Japan Author Affiliation: Sasaki S ( Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan); Daimon M ( Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan. Electronic address: daimon@muf.biglobe.ne.jp.); Kawata T ( Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan.); Miyazaki S ( Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan.); Ichikawa R ( Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan.); Maruyama M ( Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan.); Chiang SJ ( Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan.); Mahara K ( Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.); Watanabe H ( Department of Cardiology, Tokyo Bay Urayasu/Ichikawa Medical Center, Chiba, Japan.); Sumiyoshi T ( Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.); Tomoike H ( Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.); Daida H ( Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan.) |
| Abstract |
BACKGROUND: Elevated plasma B-type natriuretic peptide (BNP) is a predictor of outcome and helpful for risk stratification in aortic stenosis (AS). However, left ventricular (LV) diastolic dysfunction progresses with aging and may also influence plasma BNP levels in elderly patients. We hypothesized that plasma BNP levels may be influenced by age in severe AS, and that factors that affect the elevation of plasma BNP levels may be different between elderly and younger patients with AS. METHODS: We performed echocardiography in 341 patients with severe AS [aortic valve area (AVA)<1.0cm(2)] and classified them into two groups by age (elderly ≥75 years old, n=201; younger patients <75 years old, n=140). We used multivariate linear regression analysis to assess the factors that determine plasma BNP levels in both groups. RESULTS: Age was found to be one of the independent determinants of plasma BNP levels in all patients (ß=0.135, p=0.005). Although AVA was similar in the two groups, plasma BNP levels and E/e' were significantly higher in elderly than younger patients [133.0 (IQR, 73.3-329.7)pg/dl vs 92.8 (IQR, 40.6-171.8)pg/dl, p<0.01; 20±8 vs 16±6, p<0.01, respectively). In multivariate stepwise linear regression analysis, AVA index, LV ejection fraction, mass index, E/e', estimated systolic pulmonary artery pressure (eSPAS), and the presence of atrial fibrillation were independent determinants of plasma BNP levels in younger patients. In contrast, the independent determinants of plasma BNP levels in elderly patients were LV ejection fraction, mass index, E/e', eSPAS, the presence of atrial fibrillation, age, and hemoglobin levels, but not AVA index. CONCLUSIONS: There may be differences in the factors that influence plasma BNP levels between elderly and younger patients with severe AS. In elderly patients, plasma BNP levels may be influenced more by these factors than AS severity compared with younger patients. |
| File Format |
HTM / HTML |
| ISSN |
09145087 |
| Issue Number |
6 |
| Volume Number |
64 |
| e-ISSN |
18764738 |
| Journal |
Journal of Cardiology |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2014-12-01 |
| Publisher Place |
Netherlands |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Cardiology Aortic Valve Stenosis Blood Biological Markers Natriuretic Peptide, Brain Age Factors Aged Aging Physiopathology Echocardiography Female Humans Male Multivariate Analysis Severity Of Illness Index Comparative Study Journal Article Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Cardiology and Cardiovascular Medicine |
