| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Okazaki, Hirotake Shirakabe, Akihiro Hata, Noritake Yamamoto, Masanori Kobayashi, Nobuaki Shinada, Takuro Tomita, Kazunori Tsurumi, Masafumi Matsushita, Masato Yamamoto, Yoshiya Yokoyama, Shinya Asai, Kuniya Shimizu, Wataru |
| Description |
Country affiliation: Japan Author Affiliation: Okazaki H ( Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan.); Shirakabe A ( Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan. Electronic address: s6042@nms.ac.jp.); Hata N ( Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan.); Yamamoto M ( Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan.); Kobayashi N ( Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan.); Shinada T ( Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan.); Tomita K ( Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan.); Tsurumi M ( Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan.); Matsushita M ( Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan.); Yamamoto Y ( Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan.); Yokoyama S ( Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan.); Asai K ( Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.); Shimizu W ( Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.) |
| Abstract |
BACKGROUND: No scoring system for assessing acute heart failure (AHF) has been reported. METHODS AND RESULTS: Data for 824 AHF patients were analyzed. The subjects were divided into an alive (n=750) and a dead group (n=74). We constructed a predictive scoring system based on eight significant APACHE II factors in the alive group [mean arterial pressure (MAP), pulse, sodium, potassium, hematocrit, creatinine, age, and Glasgow Coma Scale (GCS); giving each one point], defined as the APACHE-HF score. The patients were assigned to five groups by the APACHE-HF score [Group 1: point 0 (n=70), Group 2: points 1 and 2 (n=343), Group 3: points 3 and 4 (n=294), Group 4: points 5 and 6 (n=106), and Group 5: points 7 and 8 (n=11)]. A higher optimal balance was observed in the APACHE-HF between sensitivity and specificity [87.8%, 63.9%; area under the curve (AUC)=0.779] at 2.5 points than in the APACHE II (47.3%, 67.3%; AUC=0.558) at 17.5 points. The multivariate Cox regression model identified belonging to Group 5 [hazard ratio (HR): 7.764, 95% confidence interval (CI) 1.586-38.009], Group 4 (HR: 6.903, 95%CI 1.940-24.568) or Group 3 (HR: 5.335, 95%CI 1.582-17.994) to be an independent predictor of 3-year mortality. The Kaplan-Meier curves revealed a poorer prognosis, including all-cause death and HF events (death, readmission-HF), in Group 5 and Group 4 than in the other groups, in Group 3 than in Group 2 or Group 1, and in Group 2 than in Group 1. CONCLUSIONS: The new scoring system including MAP, pulse, sodium, potassium, hematocrit, creatinine, age, and GCS (APACHE-HF) can be used to predict adverse outcomes of AHF. |
| File Format |
HTM / HTML |
| ISSN |
09145087 |
| Issue Number |
6 |
| Volume Number |
64 |
| e-ISSN |
18764738 |
| Journal |
Journal of Cardiology |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2014-12-01 |
| Publisher Place |
Netherlands |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Cardiology Apache Heart Failure Diagnosis Aged Aged, 80 And Over Area Under Curve Female Glasgow Coma Scale Mortality Humans Intensive Care Units Male Prognosis Sensitivity And Specificity Evaluation Studies Journal Article |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Cardiology and Cardiovascular Medicine |
